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CD14 — RELA

Pathways - manually collected, often from reviews:

• KEGG Amoebiasis: Complex of CD14-TLR2-TLR4 → NFKB1/RELA (protein-protein, activation)

Text-mined interactions from Literome

Jeon et al., Immunopharmacology 2000 : In the present study, we investigated the role of CD14 and complement receptor type 3 ( CR3 ) in mediating NO production and NF-kappaB/Rel activation induced by angelan and LPS
Corsini et al., Eur J Pharmacol 2001 : The binding of lipopolysaccharide to its receptor CD14 activates protein kinase C and nuclear factor-kappaB (NF-kappaB)
Müller et al., Immunology 2001 (Translocation, Genetic) : An approximately 70 % decrease of lipopeptide induced NFkappaB translocation and an about 50 % reduction of nitric oxide ( NO ) release was observed in the presence of anti-CD14
Jeon et al., Int Immunopharmacol 2001 : In conclusion, we demonstrate that angelan induces NF-kappa B/Rel activation through the CD14 and CR3 membrane receptor and p38 kinase that is critically involved in the signal transduction leading to NF-kappa B/Rel activation in murine macrophages
Maeda et al., J Biol Chem 2001 (Stomach Neoplasms) : In conclusion, H. pylori induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4
Narayanan et al., Cell Biol Int 2002 : CD14 dependent activation of NF-kappaB by filarial parasitic sheath proteins ... Herein we provide evidence that FPS activation of NF-kappaB can be augmented by the cell surface expression of CD14 ... These observations suggest that the capacity of certain lung epithelial cells to interact with microfilarial antigens, activate NF-kappaB in a CD14 dependent manner and produce pro-inflammatory cytokines may be a contributory factor to immune responses manifested by tropical pulmonary eosinophilia
Muroi et al., Infect Immun 2002 : These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS induced activation of NF-kappaB through human CD14/TLR4/MD-2
Schilling et al., Infect Immun 2003 : The LPS receptor complex utilized by the bladder epithelial cell lines included CD14 and Toll-like receptors, and signaling involved the activation of NF-kappaB and p38 mitogen activated protein kinase
Hamann et al., Infect Immun 2005 (Acute-Phase Reaction) : Here, we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to CD14 and inhibits LPS induced nuclear translocation of NF-kappaB , although cellular uptake of R-type LPS was found to be increased by hd-LBP
Jeyaseelan et al., Infect Immun 2005 (Respiratory Distress Syndrome, Adult) : Our results show that CD14 and TLR4 are necessary for low-dose ( 300-microg/ml ) LPS induced microvascular leakage, NF-kappaB activation, neutrophil influx, cytokine and chemokine ( KC, macrophage inflammatory protein 2, tumor necrosis factor alpha, interleukin-6 ) expression, and subsequent lung damage
Ikeda et al., Immunopharmacol Immunotoxicol 2005 : NF-kappaB activation via TLR2, TLR1/ TLR2, TLR2/TLR6, and TLR4/MD-2/CD14 also was enhanced by stimulation with ZWS and ZWIS
Phan et al., Gene 2006 (Burns...) : CD14 dependent modulation of NF-kappaB alternative splicing in the lung after burn injury
Liu et al., Acta Pharmacol Sin 2006 (Drug-Induced Liver Injury) : Upregulation of TNF-alpha and IL-6 mRNA might be related to increases in LBP and CD14 mRNA expression and activation of NF-kappaB
Hayashi et al., Journal of thrombosis and haemostasis : JTH 2006 : Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation : involvement of membrane bound CD14 and toll-like receptor-4 ... Antirat CD14 and antirat TLR-4 antibodies inhibited LPS induced NFkappaB activation, and a NFkappaB inhibitor suppressed LPS induced decreased PS expression in both cells
Ji et al., Zhong Xi Yi Jie He Xue Bao 2006 : QGHXR could down regulate the expressions of membrane receptors CD14 and TLR(4) and inhibit the expressions of NF-kappaB and TNF-alpha
Gaudreault et al., J Virol 2007 : NF-kappaB activation in HEK293-TLR2 cells ( HEK293 cells transfected with TLR2 ) by EBV was not enhanced by the presence of CD14
Nareika et al., J Endocrinol 2008 : Further investigations using transcription factor activity assays and gel shift assays revealed that high glucose augmented LPS stimulated CD14 expression by enhancing transcription factor nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1) activities
He et al., Clinical and vaccine immunology : CVI 2009 (Mycoplasma Infections) : The activity of NF-kappaB was synergically augmented by cotransfected TLR1, TLR6, and CD14
Chun et al., Int Immunopharmacol 2010 (Necrosis) : CD14 played a significant role in the activation of NF-kappaB in response to necrotic cells in the presence or absence of TLR2
Watson et al., Brain Behav Immun 2010 (Encephalitis) : The evidence suggests that these changes are a likely consequence of increased hippocampal expression of CD14 and TLR4, and NFkappaB activation in SIGIRR ( -/- ) mice
Medvedev et al., J Immunol 1998 : This study was undertaken to evaluate the role of CD14 and complement receptors type 3 ( CR3 ) and 4 ( CR4 ) in mediating TNF release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS )