Gene interactions and pathways from curated databases and text-mining

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HMGB1 — IRF6

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hasunuma et al., J Endotoxin Res 2002 (Shock, Septic) : The role of high mobility group-1 protein (HMG-1) in LPS- and TNF-alpha induced lethal shock in galactosamine (GalN) sensitized mice was investigated
Chen et al., J Leukoc Biol 2004 (Endotoxemia) : Here, we demonstrated that genetic disruption of CD14 expression abrogated LPS induced TNF production but only partially attenuated LPS induced HMGB1 release in cultures of primary murine peritoneal macrophages ... Pharmacological suppression of p38 or ERK1/2 MAPK with specific inhibitors ( SB203580, SB202190, U0126, or PD98059 ) significantly attenuated LPS induced TNF production but failed to inhibit LPS induced HMGB1 release ... Consistently, an endogenous, immunosuppressive molecule, spermine, failed to inhibit LPS induced activation of p38 MAPK and yet, still significantly attenuated LPS mediated HMGB1 release
Mullins et al., Scand J Immunol 2004 : Here, we report that HMGB1 is released from human umbilical vein endothelial cells ( HUVEC ) in response to lipopolysaccharide (LPS) and tumour necrosis factor (TNF)-alpha
Tang et al., Shock 2005 (Endotoxemia) : Heat shock pretreatment significantly inhibited LPS induced release of HMGB1 and the translocation of HMGB1 from the nucleus to the cytoplasm in RAW 264.7 cells ... These findings suggest that the release of HMGB1 by LPS activated macrophages is a late event in the pathogenesis of sepsis and that HSR could inhibit the release and translocation of HMGB1 induced by LPS
Killeen et al., J Pharmacol Exp Ther 2006 : Treating these cells with pyrrolidine dithiocarbamate, SN50 ( amino acid sequence AAVALLPAVLLALLAPVQRKRQKLMP ) or 5- ( thien-3-yl ) -3-aminothiophene-2-carboxamide ( SC-514 ) also inhibited LPS induced NF-kappaB DNA binding, but these compounds failed to inhibit LPS induced HMGB1 secretion ... Incubating RAW 264.7 cells with either oltipraz or DL-sulforaphane inhibited LPS induced HMGB1 secretion
Jiang et al., J Immunol 2006 : In these experiments, 1400W, an inhibitor of NO production by the inducible NO synthase, reduced HMGB1 release stimulated by LPS, but not poly ( I:C ), whereas neutralizing IFN-alpha prevented HMGB1 release induced by poly ( I:C ), but not LPS ... Furthermore, inhibition of JNK activation attenuated HMGB1 release induced by either LPS or poly ( I:C ) ... Together, these experiments indicate that, although both LPS and poly ( I:C ) induce HMGB1 release from RAW 264.7 cells and murine macrophages, the response is differentially dependent on NO and IFN-alpha
Jiang et al., J Immunol 2007 : In these experiments, using RAW 264.7 cells as a model, LPS and poly ( I:C ) caused HMGB1 release into the medium whereas CpG ODN failed to induce this response
El Gazzar et al., Inflamm Res 2007 (Inflammation) : LPS induced HMGB1 release at 8 h and reached a peak at 48 h. Significant ( p < 0.05 ) production of TNFalpha, IL-1beta, IL-10, and TGF-beta1 was seen after 8 h
Zhao et al., Zhonghua Gan Zang Bing Za Zhi 2007 : LPS could increase HMGB1 expression of HC and KC and HMGB1 release from KC, but not from HC
Liu et al., Zhonghua Nei Ke Za Zhi 2007 : Blocking of Rip2 could attenuate LPS induced TNFalpha and HMGB1 production
Jiang et al., Mol Immunol 2008 : As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS , TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Liu et al., Shock 2008 (Inflammation) : These results indicate that KLF4 plays an important role in regulating the expression of HMGB1 in normal condition, as well as the translocation and release of HMGB1 in response to LPS
Zhang et al., J Immunol 2008 : Additionally, LPS induced serine phosphorylation of HMGB1 , which correlated with an interaction between CaMKIV and HMGB1 and with CaMKIV phosphorylation of HMGB1 in vitro ... Similarly, whereas CaMKIV ( +/+ ) Mphi showed serine phosphorylation of HMGB1 in response to LPS , this phosphorylation was attenuated in CaMKIV ( -/- ) Mphi
Hagiwara et al., Crit Care Med 2009 (Acute Lung Injury...) : Likewise, LPS induced secretion of proinflammatory cytokines and HMGB1 protein was inhibited by enalapril
Tang et al., Am J Respir Cell Mol Biol 2009 (MAP Kinase Signaling System...) : Quercetin prevents LPS induced high-mobility group box 1 release and proinflammatory function ... Quercetin and autophagic inhibitor, wortmannin, inhibited LPS induced type-II microtubule associated protein 1A/1B-light chain 3 production and aggregation, as well as HMGB1 translocation and release, suggesting a potential association between autophagy and HMGB1 release
Nagato et al., Crit Care Med 2009 (Disease Models, Animal...) : The increased levels of inflammatory cytokines and plasma HMGB1 induced by LPS in this rat model were improved by the administration of ART-123 ; additionally, reduced liver dysfunction and increased survival rate were observed
Hagiwara et al., Shock 2010 (Acute Lung Injury...) : LPS induced secretion of proinflammatory cytokines and HMGB1 protein was inhibited by treatment with rTM
Murakami et al., Int Immunol 2009 (Shock, Septic) : LPS stimulation induced the production of inflammatory cytokines and anandamide and release of HMGB1 from RAW264.7 cells
Feghali et al., Oral Microbiol Immunol 2009 : LPS from A. actinomycetemcomitans, P. gingivalis, and E. coli significantly induced the production of HMGB1 in a time dependent manner
Liu et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009 (Sepsis) : Two kinds of cytokines, IL-6 and IL-8 could be up-regulated by LPS and low concentration of HMGB1, and HMGB1 acted as an inhibitor of LPS to down-regulate the expression and release of IL-6 and IL-8 from HepG2 cells
Qin et al., J Immunol 2009 (Arthritis, Experimental) : These results demonstrate that HMGB1 enhances the proinflammatory activity of LPS by promoting the phosphorylation of MAPK p38 and by the activation of NF-kappaB through RAGE
Nabeyama et al., Proc Natl Acad Sci U S A 2010 (Cell Transformation, Neoplastic...) : Macrophages from xCT ( mu/mu ) mice showed cell death in association with the excessive release of high mobility group box chromosomal protein 1 upon stimulation with LPS , suggesting that xCT deficiency causes unremitting inflammation because of the impaired survival of activated macrophages at the inflammatory site
Hagiwara et al., Shock 2011 (Inflammation) : Clopidogrel sulfate pretreatment also reduced LPS induced HMGB1 expression in lung and liver tissues
Li et al., PloS one 2011 (Disease Susceptibility...) : The protection was associated with a significant reduction in systemic HMGB1 accumulation in vivo, and parallel inhibition of IFN-?- or LPS induced HMGB1 release in vitro
Li et al., Biochem Pharmacol 2011 : Furthermore, EGCG stimulated LC3-II production and autophagosome formation, and inhibited LPS induced HMGB1 up-regulation and extracellular release
Wu et al., J Surg Res 2012 : LPS induces HMGB1 relocation and release by activating the NF-?B-CBP signal transduction pathway in the murine macrophage-like cell line RAW264.7
Zeng et al., Surgery 2012 (Genetic Predisposition to Disease...) : The rs2249825 SNP and the haplotype TCG were significantly associated with LPS induced HMGB1 production by peripheral blood leukocytes
Jang et al., Antioxid Redox Signal 2012 (Sepsis) : EP significantly inhibited the lipopolysaccharide (LPS) stimulated inducible nitric oxide synthase (iNOS) expression and high-mobility group box 1 (HMGB1) release in RAW 264.7 cells ... The inhibitory effect of EP on LPS stimulated iNOS expression and HMGB1 release was reversed by transfection with siHO-1RNA in RAW 264.7 cells, but EP failed to reduce them in HO-1 ( -/- ) peritoneal macrophages treated with LPS
Yang et al., Food Chem Toxicol 2012 : In this study, we investigated this question by monitoring the effect of OA on lipopolysaccharide (LPS) mediated release of HMGB1 and the HMGB1 mediated modulation of inflammatory responses in human umbilical vein endothelial cells ( HUVECs )
Yin et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012 : LPS can induce HMGB1 translocation from nucleus to cytoplasm and across cellular membrane to the outside of CFs at a time dependent manner
Tseng et al., PloS one 2012 (Acute Lung Injury) : This post-treatment also significantly attenuated LPS induced activation of nuclear factor-?B ( NF-?B ) and the release of high mobility group box 1 (HMGB1) in lung tissues
Zhu et al., Evidence-based complementary and alternative medicine : eCAM 2012 : We found that MBC extract dose-dependently attenuated LPS induced release of HMGB1 and several chemokines in macrophage cultures
Hwang et al., Mediators Inflamm 2012 : Among the ligands of PPAR, the effect of rosiglitazone, a specific ligand for PPAR?, was superior in the inhibition of HMGB1 release induced by LPS
Lee et al., Biochem Biophys Res Commun 2013 (Inflammation) : Berberine significantly inhibited the LPS stimulated NO production and HMGB1 release in macrophages ... The inhibitory effect of berberine on LPS stimulated NO and HMGB1 release was reversed by siRNA-Nrf2, SB203580 ( p38 MAPK inhibitor ) and zinc protoporphyrin ( ZnPP ; HO-1 inhibitor ) within macrophages
Cao et al., PloS one 2013 (Peritonitis) : In cultured HMrSV5 cells, LPS actively induced HMGB1 nuclear-cytoplasmic translocation and release in a time and dose dependent fashion
Pan et al., Chin Med J (Engl) 2013 : Using cultures of peritoneal macrophages or RAW264.7 cells, in vitro LPS stimulation induced the release of HMGB1 in an IRF-1 dependent manner ... And the janus associated kinase ( JAK ) -IRF-1 signal pathway appeared to participate in the signaling mechanisms of LPS induced HMGB1 release by mediating acetylation of HMGB1 ... IRF-1 plays a role in LPS induced release of HMGB1 and therefore may serve as a novel target in sepsis
Kawasaki et al., J Trauma Acute Care Surg 2013 : In this study, we investigated the effects of DEX on lipopolysaccharide (LPS) induced production of tumor necrosis factor a, interleukin 6 (IL-6), IL-8, and high-mobility group box 1 protein in human whole blood
Hutchison et al., Glia 2013 : Knockdown of miR-181 enhanced LPS induced production of pro-inflammatory cytokines ( TNF-a, IL-6, IL-1ß, IL-8 ) and HMGB1 , while overexpression of miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine IL-10
Huang et al., Mol Med Report 2013 : LPS induced secretion of the late pro-inflammatory cytokine HMGB1 by liver cells is characterized by a late phase of release and smaller quantity, and the process of HMGB1 secretion appears to be associated with HMGB1 translocation
Li et al., Mol Med 2013 : It was previously unknown whether panx-1 channel blockers can abrogate lipopolysaccharide (LPS) induced PKR activation and HMGB1 release in innate immune cells ... Here we demonstrated that a major gancao ( licorice ) component ( glycyrrhizin, or glycyrrhizic acid ) derivative, carbenoxolone ( CBX ), dose dependently abrogated LPS induced HMGB1 release in macrophage cultures with an estimated IC50 ˜ 5 µmol/L ... Collectively, these results suggested that CBX blocks LPS induced HMGB1 release possibly through impairing PKR activation, supporting the involvement of PKR in the regulation of HMGB1 release