Shimada et al., Mol Endocrinol 2006
:
Conversely, AREG but not FSH induced Ptsg2 mRNA at 0.5 h with peak expression of Ptgs2 and Areg mRNAs at 4 h, processes blocked by the EGF receptor tyrosine kinase inhibitor AG1478 ( AG ), PD98059, and NS398 ... PGE2 reversed the inhibitory effects of AG on AREG induced expression of Areg but not Ptgs2 , placing Ptgs2 downstream of EGF-R signaling
Al-Salihi et al., Cell Signal 2007
:
Both transforming growth factor-alpha and amphiregulin were released in response to over-expression of cyclooxygenase-2 , but betacellulin and heparin binding EGF-like growth factor were not