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ARF4 — KDM6B
Text-mined interactions from Literome
Barradas et al., Genes Dev 2009
:
In human fibroblasts,
JMJD3 activates INK4a, but not
ARF , and causes p16(INK4a) dependent arrest ... In mouse embryo fibroblasts,
Jmjd3 activates both Ink4a and
Arf and elicits a p53 dependent arrest, echoing the effects of RAS in this system ... Our findings directly implicate
JMJD3 in the
regulation of
INK4a/ARF during oncogene induced senescence and suggest that JMJD3 has the capacity to act as a tumor suppressor
Solá et al., PloS one 2011
:
In addition, the histone H3 lysine 27-specific demethylase
JMJD3 induces
ARF expression, thereby stabilizing p53 in mouse embryonic fibroblasts