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CASP10 — TNFRSF10B

Pathways - manually collected, often from reviews:

• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: Caspase 3 (CASP3) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → APO-2L (TNFSF10) (modification, collaborate)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: APO-2L (TNFSF10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• NCI Pathway Database TRAIL signaling pathway: Caspase 10 (CASP10) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → Caspase 10 (tetramer) complex (CASP10) (modification, activates)
  Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: CASP10 → TNFRSF10B (indirect_complex) Wang et al., Proc Natl Acad Sci U S A 2001, Sprick et al., EMBO J 2002*
• Reactome Reaction: CASP10 → TNFRSF10B (reaction) Wang et al., Proc Natl Acad Sci U S A 2001, Sprick et al., EMBO J 2002*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TNFRSF10B — CASP10 (association, biochemical) Gajate et al., J Biol Chem 2005
• IRef Biogrid Interaction: TNFRSF10B — CASP10 (physical association, affinity chromatography technology) MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: Complex of 17 proteins MacFarlane et al., J Biol Chem 1997
• IRef Intact Interaction: Complex of 21 proteins (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of TNFRSF10B-TNFSF10-CFLAR-CASP8-FADD-CASP10 (association, pull down) Horova et al., FEBS J 2013

Text-mined interactions from Literome

Earel et al., Cancer Res 2006 (Urinary Bladder Neoplasms) : The increased TRAIL-R2 levels also resulted in accelerated death inducing signaling complex ( DISC ) formation, caspase activation, and loss of mitochondrial membrane potential, which all contributed to the increase in tumor cell death
Mazumdar et al., PloS one 2012 : Gelsolin modulation of cell death using this fragment involved upregulation of TRAIL-R1 and TRAIL-R2 , and involved caspase 3 activation by extrinsic pathway