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FYN — SHC1

Pathways - manually collected, often from reviews:

• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Caveolin-1/FYN complex (CAV1-ITGB1-ITGA1-FYN) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Focal adhesion: FYN → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• Reactome Reaction: FYN → SHC1 (reaction) Gross et al., J Biol Chem 1999, Humphries et al., J Biol Chem 2004, Reeve et al., J Immunol 2009, Ormsby et al., Blood 2011, Bubeck Wardenburg et al., J Biol Chem 1996, Deckert et al., Immunity 1996
• WikiPathways Focal Adhesion: FYN → SHC1/SHC3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: FYN — SHC1 (direct interaction, pull down) Weng et al., Mol Cell Biol 1994*
• IRef Ophid Interaction: FYN — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shiraishi et al., Endocrinology 2006 : The LHR mediated phosphorylation of the EGFR and Shc , the activation of Ras, and the phosphorylation of ERK1/2 are inhibited by expression of a dominant negative mutant of Fyn , a member of the Src family kinases (SFKs) expressed in MA-10 cells and by PP2, a pharmacological inhibitor of the SFKs
Li et al., Proc Natl Acad Sci U S A 1996 : Moreover, tyrosine phosphorylation of Shc was induced by the overexpression of the activated Fyn