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MMP2 — ROCK1
Text-mined interactions from Literome
Do et al., Mol Cancer Res 2007
(Ovarian Neoplasms) :
Inhibition of
Rho-kinase/ROCK enhanced both LPA stimulated loss of stress fibers and
pro-MMP-2 activation
Xue et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008
:
Our aim was to test the anticancer
effects of
Rho/ROCK inhibitor, Y-27632, including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of
matrix metalloproteinase ( MMP ) and tumor progression
Ispanovic et al., Am J Physiol Cell Physiol 2008
:
ROCK inhibition rapidly
increased cell surface localization of MT1-MMP and increased PI3K activity, which was required for
MMP-2 activation
Sun et al., Clin Exp Pharmacol Physiol 2010
:
6. The results of the present study indicate that PDE5 inhibition suppresses
RhoA/ROCK mediated
MMP-2 production by PASMC, which may contribute to the regulation of pulmonary vascular remodelling
Matsuoka et al., Clin Exp Metastasis 2011
(Adenocarcinoma, Scirrhous...) :
The
effect of
ROCK inhibitor, Y-27632 on the mRNA expression of the integrin family and
MMP in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis