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ACAN — TNF
Text-mined interactions from Literome
Stöve et al., Pathobiology 2000
(Osteoarthritis, Knee) :
Quantitative RT-PCR reaction was used to estimate the messenger RNA ( mRNA ) of three different metabolites
[tumor-necrosis-factor stimulated gene 6 ( TSG-6 ), stromelysin-1 ( MMP-3 ) and
aggrecan (AGG) ]
Müller et al., Cytokine 2008
:
TNF-alpha suppressed collagen type II and
aggrecan , but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls
Voigt et al., Arthritis Res Ther 2009
:
TNFalpha increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression, whereas collagen type I was decreased, and
aggrecan , collagen type II as well as MMP-1, -2, -13 and ADAMTS-5 were variably
affected
Tian et al., Am J Pathol 2013
(Intervertebral Disc Degeneration) :
Lentiviral transduction with shRNA plasmids shp65, shp52, shIKK-a, and shIKK-ß significantly decreased
TNF-a dependent increase in ADAMTS-4 and -5 levels and
aggrecan degradation ... Silencing of either ADAMTS-4 or -5 resulted in reduction in
TNF-a dependent
aggrecan degradation in NP cells