Gene interactions and pathways from curated databases and text-mining

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ACAN — TNF

Text-mined interactions from Literome

Stöve et al., Pathobiology 2000 (Osteoarthritis, Knee) : Quantitative RT-PCR reaction was used to estimate the messenger RNA ( mRNA ) of three different metabolites [tumor-necrosis-factor stimulated gene 6 ( TSG-6 ), stromelysin-1 ( MMP-3 ) and aggrecan (AGG) ]
Müller et al., Cytokine 2008 : TNF-alpha suppressed collagen type II and aggrecan , but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls
Voigt et al., Arthritis Res Ther 2009 : TNFalpha increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression, whereas collagen type I was decreased, and aggrecan , collagen type II as well as MMP-1, -2, -13 and ADAMTS-5 were variably affected
Tian et al., Am J Pathol 2013 (Intervertebral Disc Degeneration) : Lentiviral transduction with shRNA plasmids shp65, shp52, shIKK-a, and shIKK-ß significantly decreased TNF-a dependent increase in ADAMTS-4 and -5 levels and aggrecan degradation ... Silencing of either ADAMTS-4 or -5 resulted in reduction in TNF-a dependent aggrecan degradation in NP cells