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HMGCR — TNF

Text-mined interactions from Literome

Gallardo et al., Biochem Biophys Res Commun 2003 : We have examined the effects of tumor necrosis factor alpha (TNF alpha) and its second messenger, ceramide, on HMGCoA reductase , the rate limiting enzyme in the mevalonate pathway
Nübel et al., FASEB J 2004 (Neoplasms) : As shown by ELISA and FACS analyses, HMG-CoA reductase inhibitors ( e.g., lovastatin ) impair the TNF-alpha stimulated increase in E-selectin protein expression
Nishimura et al., Horm Metab Res 2006 (Bacteroidaceae Infections...) : Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression, both tumor necrosis factor-alpha and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly up-regulated HMG-CoA reductase gene expression
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : Simvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, which is known to activate PI3K/Akt, blocks TNF-alpha- and insulin induced PAI-1 expression
Park et al., Arch Pharm Res 2008 : Simvastatin, a HMG-CoA reductase inhibitor, suppressed both tumor necrosis factor (TNF)-alpha- and angiotensin (Ang) II-induced monocyte adhesion to endothelial cells ( an initial step in vascular inflammation ) and reactive oxygen species ( ROS ) production
Araújo et al., Biomed Pharmacother 2010 (Disease Models, Animal...) : The inhibitory function of atorvastatin on multiple parameters of main components of inflammatory angiogenesis revealed in this study is clearly associated with the modulatory effects of HMG-CoA reductase on VEGF, TNF-alpha and TGF-beta1 production
Hardardóttir et al., Lymphokine Cytokine Res 1994 (Inflammation) : TNF or IL-1 increased hepatic HMG CoA reductase mRNA levels by 3.5- and 3-fold, respectively ... TNF + IL-1 increased HMG CoA reductase mRNA levels by 7-fold
Memon et al., Endocrinology 1993 : Moreover, TNF and IL-1 produced a 2.3- and 2.1-fold increase in hepatic HMG-CoA reductase activity, respectively