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CISH — SOCS2
Text-mined interactions from Literome
Karlsson et al., Mol Cell Endocrinol 1999
:
Here we demonstrate that
Socs-2 and Cis mRNA expression in rat liver is
dependent on the presence of growth hormone (GH), and that GH induce
Cis mRNA expression in cultures of primary rat hepatocytes
Dogusan et al., J Neuroimmunol 2000
(Leukemia) :
In tonsillar cells,
CIS expression was increased and
SOCS-2 was
induced by IL-1beta, IL-6, PRL and GH
Johnson et al., J Endocrinol 2001
(Sepsis) :
GH induced
SOCS-2 and CIS in the CLP rat despite resistance with respect to IGF-I generation, and parenteral feeding
induced CIS in the CLP rat
Cwikel et al., Exp Hematol 2001
:
However,
CIS-1 was
induced by PRL < IL-3 < PRL+IL-3, whereas
CIS-2 expression was induced by PRL = IL-3 < PRL+IL-3
Lavens et al., J Cell Sci 2006
:
Furthermore, although SOCS2 does not associate with Y985 of the leptin receptor, we find that
SOCS2 can
block interaction of
CIS with this position
Piessevaux et al., J Biol Chem 2006
:
This
SOCS2 effect was
SOCS box
dependent , required recruitment of the elongin BC complex, and coincided with degradation of target SOCS proteins