Gene interactions and pathways from curated databases and text-mining

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NOS3 — PDE5A

Text-mined interactions from Literome

Gebska et al., Cardiovasc Res 2011 (Hypertension, Pulmonary) : Treatment of human endothelium with PDE5A inhibitors resulted in a significant increase in NOS3 activity, whereas overexpression of PDE5A using an adenoviral vector, both in vivo and in cell culture, resulted in decreased NOS3 activity and endothelium dependent vasodilation
Wu et al., Int J Immunopathol Pharmacol 2011 : KMUP-1 ( 0.001-0.1 microM ) concentration dependently increased eNOS in normoxia and did not inhibit phosphodiesterase-5A (PDE-5A) in hypoxic cells