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NOS3 — PDE5A
Text-mined interactions from Literome
Gebska et al., Cardiovasc Res 2011
(Hypertension, Pulmonary) :
Treatment of human endothelium with PDE5A inhibitors resulted in a significant increase in NOS3 activity, whereas overexpression of
PDE5A using an adenoviral vector, both in vivo and in cell culture,
resulted in decreased
NOS3 activity and endothelium dependent vasodilation
Wu et al., Int J Immunopathol Pharmacol 2011
:
KMUP-1 ( 0.001-0.1 microM ) concentration dependently increased
eNOS in normoxia and did not
inhibit phosphodiesterase-5A (PDE-5A) in hypoxic cells