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LEP — MMP9
Text-mined interactions from Literome
Castellucci et al., Mol Hum Reprod 2000
:
We demonstrate that
leptin increases, in a dose dependent manner, the secretion of immunoreactive MMP-2 and fFN and
enhances the activity of
MMP-9 in cultured cytotrophoblastic cells
Park et al., Exp Mol Med 2001
(Arteriosclerosis...) :
Leptin also induced
increases of MMP-2,
MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Quinton et al., Am J Reprod Immunol 2003
:
Expression of leptin receptor isoforms in vitro : lack of
effects of
leptin on endometrial cytokine and
MMP production ... The
effect of
leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and
matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ...
Leptin had no effect on cytokine and
MMP production by these cells
Schulz et al., Biol Reprod 2004
:
Our results suggest that
leptin may play a role in the establishment of the placenta during early pregnancy and that this function is
dependent on
MMP activity
Simopoulou et al., Osteoarthritis Cartilage 2007
(Obesity...) :
Also,
leptin had a detrimental effect on chondrocyte proliferation and
induced IL-1beta production and
MMP-9 and MMP-13 protein expression
Schram et al., J Mol Cell Cardiol 2008
:
Here we investigated the
effects of
leptin , circulating levels of which are typically increased in obese individuals, on
MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Yeh et al., Glia 2009
(Brain Neoplasms...) :
In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of MMP-2 and
MMP-9 was
increased in response to
leptin stimulation
Bao et al., Mol Biol Rep 2010
:
Leptin significantly
increased both gene and protein levels of MMP-2,
MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013
(Aortic Aneurysm, Abdominal...) :
Leptin and leptin receptor antigen were evident in all AAAs, and leptin,
MMP-9 , and MMP-12 mRNA was
increased relative to age matched nondilated controls