◀ Back to MAP3K1
MAP3K1 — MAPK3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK3
→
MAP3K1
(increases, MAP3K1 Activity, MAPK3 Activity)
Evidence: Expression of MEKK1-KM attenuated activation of ERK and JNK (Figures 6A and 6B). Selective activation of MEKK1 was sufficient for the activation of both MAP kinases.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Uhlik et al., Biochem Cell Biol 2004
(MAP Kinase Signaling System) :
Wiring diagrams of
MAPK regulation by
MEKK1 , 2, and 3
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
López-Pelaéz et al., Mol Biol Cell 2012
(Inflammation...) :
Cot/tpl2 is the only
MAP3K that
activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Xu et al., Proc Natl Acad Sci U S A 1995
:
MEKK1 phosphorylates MEK1 and MEK2 but does not
cause activation of
mitogen activated protein kinase