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CCND1 — PTGS2

Text-mined interactions from Literome

Wu Chen et al., Brain Res Mol Brain Res 2004 (Disease Models, Animal...) : Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo ... COX-2 activity is known to induce expression of cyclin D1 in neoplastic cells, and cyclin D1 expression can induce cell death in postmitotic neurons ... These results show that COX-2 activity is required for cyclin D1 expression after ischemia in vivo and anoxia in vitro
Luo et al., J Pharmacol Exp Ther 2007 : The continued increase of COX-2 ( up to 18 h ) resulted in increased intracellular prostaglandin E ( 2 ) and cyclin D1 expression significantly after 8 and 12 h of EGF treatment ... Dexamethasone substantially reduced EGF stimulated COX-2 expression at 3 and 6 h and cyclin D1 expression at 8 and 12 h. Pretreatment of RGM-1 cells with dexamethasone or 2'-amino-3'-methoxyflavone ( PD98059 ) -mitogen activated protein kinase kinase inhibitor ( 5 x 10 ( -5 ) M ) significantly reduced EGF stimulated pERK1/pERK2 expression
Li et al., Neurochem Res 2008 (Hypoxia, Brain) : Overexpression of COX-2 did not increase expression of cyclin D1 or phosphoretinoblastoma protein (pRb), or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model
Sheng et al., Cell Growth Differ 1997 : Taken together, the results demonstrate that TGF-beta 1 strongly induces COX-2 at both the mRNA and protein levels and suggest that this induction of COX-2 is involved in the down-regulation of cyclin D1 and inhibition of cell growth caused by TGF-beta 1 in rat intestinal epithelial cells