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CCND1 — EIF4E

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCND1 → EIF4E (directlyIncreases, CCND1 Activity)
  Evidence: Thus, mTOR also controls eIF4E function, which is particularly important in the translation of mRNAs containing a highly structured 5' untranslated region (UTR), such as the transcripts encoding cyclin D1 and the c-myc oncogene ([82]).

Text-mined interactions from Literome

Lai et al., Oncogene 2000 (Leukemia, Promyelocytic, Acute) : eIF-4E overexpression leads to increased cyclin D1 protein levels ; whereas, overexpression of PML leads to decreased cyclin D1 levels ... Neither PML nor eIF-4E cause significant changes in cyclin D1 mRNA levels
Oridate et al., Cancer Biol Ther 2005 (Carcinoma, Squamous Cell...) : siRNA mediated decrease of eIF4E has led to decreases in the expression of CCND1 , basic fibroblast growth factor and vascular endothelial growth factor
Othumpangat et al., J Biol Chem 2005 : Exposure of cells to cadmium, as well as the specific silencing of eIF4E gene, also resulted in decreased cellular levels of cyclin D1, a critical cell cycle and growth regulating gene, suggesting that the observed inhibition of cyclin D1 gene expression in the cadmium treated cells is most likely due to decreased cellular level of eIF4E
Dong et al., Breast Cancer Res Treat 2009 (Breast Neoplasms) : The downregulation of eIF4E expression significantly reduced the levels of VEGF, FGF-2 and cyclinD1 expression, suppressed cell growth, induced cell cycle arrest in G ( 0 ) /G ( 1 ) phase and subsequent apoptosis by activating caspase 3 in MCF-7 cells
Fan et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Non-Small-Cell Lung...) : However, inhibition of eIF4E/eIF4G interaction by knockdown of eIF4E effectively reduced the levels of cyclin D1 and HIF-1alpha but failed to induce DR5 expression, downregulate c-FLIP levels, or augment TRAIL induced apoptosis
Rosenwald et al., Mol Cell Biol 1993 : In these cells, increased levels of eIF-4E protein were closely followed by increases in levels of cyclin D1 protein, but the level of cyclin D1 mRNA was not increased ... We conclude that increases in cyclin D1 levels may result from increased expression of eIF-4E , and this regulation may be one determinant of cyclin D1 levels in the cell
Rousseau et al., Proc Natl Acad Sci U S A 1996 : Here, we studied the mode by which eIF-4E increases the expression of cyclin D1 and ODC