Gene interactions and pathways from curated databases and text-mining

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IL10 — POLDIP2

Text-mined interactions from Literome

Schwacha et al., Shock 2003 (Burns) : Inhibition of p38 MAP kinase activity attenuated IL-10 production and abrogated the enhanced IL-10 response induced by alphaCD11b, whereas ERK 1/2 inhibition had no effect
Kotani et al., Eur Respir J 2004 (Disease Models, Animal...) : Physiological parameters, tumour necrosis factor (TNF)-alpha, interleukin (IL)-8 and activation of mitogen activated protein kinases ( extracellular signal regulated kinase ( ERK ) 1/2, p38 and stress activated protein kinase ( SAPK ) / c-Jun N-terminal kinase (JNK) ) were measured
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : In response to TLR signals, MKP-1-deficient macrophages produced 5- to 10-fold higher IL-10 , which could be blocked by a p38 MAPK inhibitor
Kalliolias et al., J Immunol 2008 : IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38