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BCL2 — GAPDH
Text-mined interactions from Literome
Tatton et al., Eur J Ophthalmol 1999
(Glaucoma...) :
Mediated by
GAPDH binding, DES increases mitochondrial BCL-2 and
BCL-xL levels and decreases BAX levels thereby preventing the permeability transition pore (PTP) form opening and preventing apoptotic degradation
Dastoor et al., J Cell Sci 2001
:
Bcl2 overexpression
prevents nuclear translocation of
GAPDH and apoptosis in untransfected cells, but not in transfected cells that overexpress GAPDH-GFP
Maruyama et al., J Neurochem 2001
(Parkinson Disease) :
Transfection enforced
Bcl-2 overexpression and an anti-Parkinson drug, rasagiline,
prevent nuclear accumulation of
glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl ( R ) salsolinol
Jacquin et al., Cell Death Differ 2013
:
The
GAPDH dependent
Bcl-xL overexpression is able to protect a subset of mitochondria from permeabilization that are required for cellular survival from CICD ... Thus, our work suggests that
GAPDH overexpression could
induce Bcl-xL overexpression and protect cells from CICD induced chemotherapy through preservation of intact mitochondria that may facilitate tumor survival and chemotherapeutic resistance