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EGF — IGFBP3

Text-mined interactions from Literome

Edmondson et al., J Cell Physiol 1999 : Using Northern blot analysis, we found EGF and TGFbeta1 ( 50 ng/ml ) to reduce IGFBP-3 mRNA levels in keratinocytes to 51+/-12 % and 50+/-38 %, respectively, when compared with control, untreated cells
Martin et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Collectively, these findings indicate that IGFBP-3 enhances EGF signaling and proliferative effects in breast epithelial cells via increased EGF receptor phosphorylation and activation of p44/42 and p38 MAP kinase signaling pathways
Grimes et al., Endocrinology 1992 : However, in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ), insulin also induced this 30-kDa IGFBP
Barreca et al., Mol Cell Endocrinol 1992 : The stimulation of IGF-I and IGFBP secretion by EGF appears to be dose dependent with a significant increment already evident at 5 nM
Nuttinck et al., Domest Anim Endocrinol 2004 : Under defined culture conditions, IGFBP-2 and FSHR mRNA expression remained at a high level in TCM199 alone and were significantly reduced ( P < 0.05 ) in the presence of 10 ng/ml EGF after a 24 h period of in vitro maturation
Lee et al., Oncol Rep 2004 (Anoxia...) : EGF down-regulated hypoxia induced IGF-II binding protein-3 (IGFBP-3) , which may contribute to the enhancement of free IGF-II accessibility to its receptors in vivo
Mathur et al., Gynecol Oncol 2005 (Papillomavirus Infections...) : Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor ( VEGF ) and a decrease of the anti-proliferative IGF binding protein-3 (IGF-BP3)
Takaoka et al., Am J Physiol Gastrointest Liver Physiol 2006 : EGF mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I
Mochizuki et al., Growth Horm IGF Res 2006 (Endometrial Neoplasms) : However, EGF receptor phosphorylation and expression were not reduced by IGFBP-3
Mondschein et al., Endocrinology 1990 : In contrast, IGFBP-3 levels were enhanced by epidermal growth factor
Corps et al., Endocrinology 1991 : Production of this IGFBP by Swiss 3T3 cells was stimulated by 50-150 % by the mitogens bombesin, vasopressin, platelet derived growth factor, epidermal growth factor , and 12-O-tetradecanoylphorbol 13-acetate and also by IGF-I
Martin et al., J Biol Chem 2009 : IGFBP-3 potentiated EGF stimulated EGF receptor activation and DNA synthesis, and this was blocked by inhibitors of SphK activity or small interference RNA mediated silencing of SphK1, but not SphK2, expression
McIntosh et al., J Biol Chem 2010 (Breast Neoplasms...) : We have examined the effects of IGFBP-3 on EGF responses of breast epithelial cells in the context of changes in the extracellular matrix
Zhao et al., Tumour Biol 2012 (Carcinoma, Squamous Cell...) : EGF reduced the expression of IGFBP-3 in KYSE30 cells ; however, nimotuzumab could reverse the downregulation of IGFBP-3, and this result was also not observed in TE-1 cells
Hembree et al., Cancer Res 1994 (Uterine Cervical Neoplasms) : EGF suppression of IGFBP-3 is maintained even when EGF stimulated cell growth is suppressed 67 % due to the simultaneous presence of 3 ng/ml of TGF beta 1, indicating that EGF suppression of IGFBP-3 levels is independent of EGF effects on cell growth ... Moreover, the simultaneous presence of both EGF and IGF-I reduces the level of IGFBP-3 more efficiently than EGF alone
Oguchi et al., Am J Physiol 1994 : IGF-I stimulated mainly IGF-BP-3 production, but epidermal growth factor (EGF) and transforming growth factor-alpha ( TGF-alpha ) stimulated predominantly IGF-BP-4 secretion
Bachrach et al., Growth Regul 1995 (Adenocarcinoma, Follicular...) : In both cell lines, EGF or TPA stimulated IGFBP-3 production while TSH or forskolin inhibited IGFBP-3 production and reduced the stimulation of IGFBP-3 seen with EGF or TPA
Wraight et al., J Invest Dermatol 1995 : We investigated the effects of IGF-I and EGF , as well as three other skin-growth regulators, retinoic acid, basic fibroblast growth factor, and dexamethasone, on mitogenic stimulation and IGFBP-3 production in HaCaT cells ... IGF-I increased the level of IGFBP-3 in cell conditioned medium by up to twofold, whereas EGF caused a twentyfold reduction in IGFBP-3 ... In summary, EGF profoundly inhibited IGFBP-3 synthesis in basal keratinocytes, whereas IGF-I increased IGFBP-3 levels by a posttranscriptional mechanism
Oguchi et al., Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1997 : The effects of IGF-I and EGF on IGFBP secretion diminished with increasing cell differentiation