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BMP4 — EPHB2

Text-mined interactions from Literome

Yang et al., Circ Res 2005 (Hypertension, Pulmonary) : These differences were not caused by differential activation of BMP signaling pathways because exogenous BMP-4 led to phosphorylation of Smad1, p38 ( MAPK ), and ERK1/2 in both cell types
Fan et al., J Cell Physiol 2006 (Cholestasis, Extrahepatic...) : Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells ... Furthermore, BMP4 stimulated phosphorylation of Smad1 and ERK1/2 in HSCs
Zhou et al., Cardiovasc Res 2007 : Here, we demonstrate that BMP-4 not only signals through the classical Smad cascade but also activates ERK phosphorylation as an alternative pathway in human umbilical vein endothelial cells ( HUVEC ) and that Smad and ERK pathways communicate through signal crosstalk ... Quantitative in-gel angiogenesis assays in the presence or absence of MEK inhibitors demonstrate that ERK signals are necessary for BMP-4 induced capillary sprouting
Ghayor et al., Biochem Biophys Res Commun 2009 : On the other hand, BMP2 induced Erk phosphorylation ( p44/p42 ) and cell proliferation were suppressed in the presence of cAMP
Fan et al., J Cell Physiol 2009 : BMP4 induced differentiation of WB-F344 cells toward hepatocytes was mediated by increase in phosphorylation of Smad1 and ERK1/2
Otani et al., J Endocrinol 2009 : BMP2 and BMP4 also suppressed estrogen induced phosphorylation of ERK1/ERK2 and SAPK/JNK signaling, suggesting that BMP2 and BMP4 downregulate estrogen effects by attenuating ER-MAPK signaling
Zhang et al., Development 2010 : Mechanistic studies show that BMP4 inhibits FGF/ERK activity at the first stage but not at the second stage ; and IDs, as important downstream genes of BMP signaling, partially substitute for BMP4 functions at both stages
Jun et al., J Biol Chem 2010 : Because BMP signaling induces Erk activation in osteoblasts, we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability
Takeda et al., Mol Cell Endocrinol 2012 (MAP Kinase Signaling System) : Thus, the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential effects of BMP ligands on GnRH induced ERK signaling
Ge et al., J Bone Miner Res 2012 (MAP Kinase Signaling System) : Significantly, in the presence of AA, BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally dependent on ERK/MAPK activity ... Based on this work, we conclude that extracellular matrix and BMP regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly mediated by ERK rather than p38 MAPKs
Li et al., Cell stem cell 2012 : BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells ... Here, we show that, whereas LIF sustains relatively high ERK activity, BMP4 can steadily attenuate ERK activity by upregulating ERK-specific dual-specificity phosphatase 9 (DUSP9)
Li et al., Protein Cell 2012 : We recently found that while LIF signaling augments ERK activity, BMP signaling inhibits ERK activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9
Buresh-Stiemke et al., Dev Dyn 2012 (MAP Kinase Signaling System) : Exogenous BMP4 and BMP7 induced Sulf1 expression in the UGS, decreased epithelial HS 6-O sulfation, and reduced ERK1/2 activation in response to FGF10