◀ Back to RAF1

EDN1 — RAF1

Pathways - manually collected, often from reviews:

• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → MEK2 (MAP2K2) (modification, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → RAF1 (modification, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → ERK2 (MAPK1) (modification, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
  
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → MEK1 (MAP2K1) (modification, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → ERK1 (MAPK3) (modification, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: RAF1 → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
  
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → dynamin gtpase (DNM1) (translocation, collaborate)
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) → Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) (translocation, collaborate)
  
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: dynamin gtpase (DNM1) → Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1) (translocation, activates)
  

Text-mined interactions from Literome

Morishita et al., Neurosci Res 2007 : Endothelin induced ERK phosphorylation was independent of integrin ligands, and an inhibitor of G ( q/11 ), YM-254890, as well as pertussis toxin, partially inhibited endothelin stimulated phosphorylation of Raf-1 and ERK
Nakajima et al., Arch Dermatol Res 2011 (Melanoma) : Signaling analysis with specific inhibitors and immunoblots revealed that in melanoma cells treated with the extract, there was a marked deficiency in the EDN1 stimulated phosphorylation of Raf-1 , MEK, ERK, MITF and CREB
Kyriakis et al., J Biol Chem 1993 : c-Raf-1 activation is also induced by insulin, phorbol ester, thrombin, and endothelin