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MIF — MMP9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP9 → MIF (increases)
  Evidence: In a macrophage cell line and primary aortic SMCs, mRNA and protein expression for MMP-9 was found to be enhanced by MIF treatment in a dose-dependent manner (Fig. 1) [54].

Text-mined interactions from Literome

Kong et al., Atherosclerosis 2005 (Arteriosclerosis) : Macrophage migration inhibitory factor induces MMP-9 expression : implications for destabilization of human atherosclerotic plaques ... This hypothesis was investigated by examining the expression of MIF and MMP-9 in human atherosclerotic plaques using two-color immunostaining and by determining the potential role of MIF in the induction of MMP-9 expression in vascular smooth muscle cells ( VSMC ) and macrophages in vitro ... The role of MIF in MMP-9 expression was demonstrated by the ability of MIF to directly induce MMP-9 mRNA and protein expression in macrophages and in VSMCs in a dose and time dependent manner, which was blocked by a neutralizing MIF antibody ... The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques
Burger-Kentischer et al., Atherosclerosis 2006 (Aortitis...) : Importantly, the local aortic expression of ICAM-1, MMP-2 , TNF, IL-12, and CD40L was reduced by MIF blockade, as were the levels of the phospho-c-Jun and C/EBPbeta transcription factors
Pakozdi et al., Arthritis Res Ther 2006 (Arthritis, Experimental...) : In the present study, we determined the role of MIF in RA synovial fibroblast MMP production and the underlying signaling mechanisms
Yu et al., J Interferon Cytokine Res 2007 (MAP Kinase Signaling System) : Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway ... The aim of this study is to investigate the signaling mechanism by which MIF induces MMP-9 expression and activation in a murine macrophage line ( RAW264.7 ) ... This was confirmed by the findings that addition of an ERK MAP kinase inhibitor ( PD98059 ) but not a p38 inhibitor ( SB203589 ) abolished MIF induced MMP-9 expression and activation, whereas addition of a JNK inhibitor ( SP600125 ) produced a partially inhibitory effect ... The functional role of mitogen activated protein kinase kinase ( MEK ) -ERK MAP kinase in MIF induced MMP-9 expression was further confirmed by overexpressing dominant negative MEK ( DN-MEK ) and DN-ERK MAP kinases ... Interestingly, constitutive expression of a wild-type ( WT ) -MEK alone was also capable of inducing a low, but significant MMP-9 mRNA and protein expression but did not cause a further increase in MMP-9 in response to MIF
Assunção-Miranda et al., J Med Virol 2010 (Alphavirus Infections...) : The use of different strategies to block MIF action, including an anti-MIF antibody, the MIF inhibitor ISO-1 and knockout mice for the MIF gene, showed that cytokine secretion and MMP expression during infection were regulated by MIF , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade
Cavalcanti et al., PloS one 2011 (Ileitis...) : MIF also affected the expression of matrix metalloproteinase-9 (MMP-9) but not MMP-2 in the intestine of infected mice