Gene interactions and pathways from curated databases and text-mining

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MMP9 — RNF19A

Text-mined interactions from Literome

Simon et al., Exp Cell Res 2001 (Neoplasm Invasiveness...) : While dominant negative p38 and MKK-6 mutants reduced MMP-9 promoter activity in CAT assays, a construct encoding an activating mutation in the MKK-6 protein potently stimulated it
Chakrabarti et al., J Leukoc Biol 2005 (MAP Kinase Signaling System) : Inhibition of extracellular signal regulated kinase ( ERK ) 1/2 blocked IL-8 mediated MMP-9 release ; however, inhibition of p38 mitogen activated protein kinase had no effect on MMP-9 release
Furundzija et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : This involves activation of integrins and focal adhesion formation via inside-out PI3-kinase/PKC/p38 dependent signaling, but does not require MMP activation
Han et al., Oncol Res 2010 (Adenocarcinoma...) : In contrast, p38 inhibitor reduced cell growth inhibition, apoptosis, and MMP ( deltapsi ( m ) ) loss by MG132
Ranzato et al., Exp Dermatol 2011 : Zymography and Western blot analyses showed that exposure to 20 % ( v/v ) PL for 24 h induced an apparently ERK1/2- and p38 dependent , NF-kappaB independent, translational upregulation of MMP-9 in HaCaT, while HaCaT MMP-2 and fibroblast collagenases were almost unaffected
Miraglia et al., Journal of neuroinflammation 2013 (Brucellosis...) : Inhibition of p38 or Erk1/2 significantly diminished MMP-9 secretion, and totally abrogated production of this MMP when both MAPK pathways were inhibited simultaneously