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CPOX — NOS2

Text-mined interactions from Literome

Chen et al., J Biol Chem 1999 : The cyclooxygenase-2 (COX-2) inhibitors, NS-398 and indomethacin, attenuated LPS induced NO release, iNOS expression, and NF-kappaB DNA-protein complex formation
Hashimoto et al., Hypertens Res 2003 : On the other hand, the COX inhibitors, indomethacin and NS-398, had little effect on nitrite production or iNOS expression
Ejima et al., Antioxid Redox Signal 2004 (Endotoxemia) : The present article reviews our recent studies involving the role of cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia and its role in the regulation of nitric oxide synthase (NOS)2 and heme oxygenase (HO)-1
Won et al., Glia 2005 : In contrast to LO, however, the cyclooxygenase (COX) may not be involved in the regulation of LPS mediated induction of iNOS gene because COX inhibition by indomethacin ( general COX inhibitor ), SC560 ( COX-1 inhibitor ), and NS398 ( COX-2 inhibitor ) affected neither the LPS induced iNOS expression nor activation of NFkappaB
King et al., Neurosignals 2005 (Opioid-Related Disorders...) : A non-inclusive list of examples of substances reported to block or reverse opioid antinociceptive tolerance include : substance P receptor ( NK-1 ) antagonists, calcitonin gene related peptide (CGRP) receptor antagonists, nitric oxide ( NO ) synthase inhibitors, calcium channel blockers, cyclooxygenase (COX) inhibitors , protein kinase C inhibitors, competitive and non-competitive antagonists of the NMDA ( N-methyl-D-aspartate ) receptor, AMPA ( alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid ) antagonists, anti-dynorphin antiserum, and cholecystokinin (CCK) receptor antagonists
Chang et al., Cell Signal 2006 (MAP Kinase Signaling System) : LTA induced iNOS expression and NO release were inhibited by a non-selective COX inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS-398 ), an adenylyl cyclase ( AC ) inhibitor ( dideoxyadenosine, DDA ), and a protein kinase A (PKA) inhibitor ( KT-5720 )
West et al., Crit Care Med 2008 : We used nonselective and selective COX inhibitors to determine the role of COX on inducible NOS (iNOS) expression in the gastric mucosa
Ye et al., Am J Physiol Heart Circ Physiol 2008 (Disease Models, Animal...) : Activation of COX2 is dependent on iNOS
Stanley et al., Vascul Pharmacol 2009 (Diabetes Complications...) : Uterine arteries from term-pregnant, diabetic and control C57Bl6/J mice were assessed using acetylcholine ( ACh ; 10 ( -10 ) -10 ( -5 ) M ) in the presence or absence of a nitric oxide ( NO ) synthase inhibitor ( L-NNA ; 10 ( -5 ) M ), a cyclooxygenase (COX) inhibitor ( indomethacin ; 10 ( -5 ) M ) or the two in combination
Arab et al., J Biol Chem 2010 (Hyperoxia...) : This decrease in COX expression is prevented by the inhibition of inducible nitric-oxide synthase (iNOS)
Obermajer et al., Transplantation research 2012 : We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra, nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
LaPointe et al., Hypertension 1998 : Since NO has been shown to directly stimulate COX activity and the resulting prostanoids to modulate IL induction of iNOS, we questioned whether PLA2 and/or COX products are involved in IL regulation of iNOS and NO production in NVM