Gene interactions and pathways from curated databases and text-mining

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GNRH1 — PI3

Text-mined interactions from Literome

Mutiara et al., Mol Cell Endocrinol 2008 : Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor
Kanasaki et al., Neuro Endocrinol Lett 2008 : alphaT3-1 cells were transfected with alpha-subunit promoter region linked luciferase vector, and stimulated with GnRH in the presence or absence of two different PI3-kinase inhibitors, LY 294002 and wortmannin