◀ Back to MAPK3

KSR1 — MAPK3

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB1 downstream signaling: Erk1-2-active (MAPK3/MAPK1) → KSR (KSR1) (modification, activates) McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-MAP2K1_MAP2K2) → Erk1-2-active (MAPK3/MAPK1) (modification, collaborate)
  McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: Erk1-2-active (MAPK3/MAPK1) → KSR/14-3-3 (dimer)/MEK1-2 complex (KSR1-MAP2K1_MAP2K2) (modification, activates)
  McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: Erk1-2 (MAPK3/MAPK1) → KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) (modification, collaborate)
  Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
  Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: Erk1-2-active (MAPK3/MAPK1) → KSR (KSR1) (modification, activates) McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: Erk1-2 (MAPK3/MAPK1) → KSR (KSR1) (modification, collaborate) Xu et al., J Biol Chem 1999*, Howe et al., Cell 1992, McKay et al., Proc Natl Acad Sci U S A 2009, Minden et al., Science 1994, Zheng et al., J Biol Chem 1993, Huang et al., Proc Natl Acad Sci U S A 1993
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: Erk1-2 (MAPK3/MAPK1) → KSR (KSR1) (modification, collaborate) Catalanotti et al., Nature structural & molecular biology 2009, McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: assay

Text-mined interactions from Literome

Channavajhala et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Although KSR is a positive regulator of the Ras/mitogen activated protein ( MAP ) kinase pathway, the role of KSR in Cot mediated MAPK activation has not been identified
Casar et al., Mol Cell Biol 2009 : As such, we show that for cPLA(2) activation, ERK1/2 activated at lipid rafts interact with KSR1 , whereas ERK1/2 activated at the endoplasmic reticulum utilize Sef-1
Gramling et al., Cell Death Differ 2012 (Cell Transformation, Neoplastic...) : Therefore, loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development
Joneson et al., J Biol Chem 1998 : We examined the effect of mammalian KSR expression on the activation of extracellular ligand regulated ( ERK ) mitogen activated protein ( MAP ) kinase in fibroblasts