Prodromou et al., Curr Cancer Drug Targets 2003
:
Sti1 and Cdc37/p50, which associate with early Hsp90 complexes, were shown to be inhibitors of Hsp90 ATPase activity and therefore promote its ` open ' state, whereas Sba1/p23 , which associates with mature complexes, inhibits ATPase activity and stabilises the ` closed ' state
Cox et al., Cell Stress Chaperones 2004
:
Our results are consistent with a model in which p23 inhibits Hsp90 ATPase activity, thereby stabilizing ATP-Hsp90-client protein complexes