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CTNNB1 — WT1
Text-mined interactions from Literome
Amini Nik et al., Int J Cancer 2005
(Fibroma) :
Finally, we investigated a possible
role of
beta-catenin on
WT1 regulation and vice versa ... Overexpression of different
beta-catenin mutants in the HEK293T cell line did not modulate WT1 promoter activity and
WT1 did not
affect beta-catenin /TCF transcriptional activity in this cell line
Chang et al., Development 2008
:
Wt1 negatively
regulates beta-catenin signaling during testis development ... As Wt1 conditional knockout in Sertoli cells causes similar phenotypes to our stabilized beta-catenin mutants, we then investigated the relationship of Wt1 and beta-catenin in Sertoli cells and found
Wt1 inhibits
beta-catenin signaling in these cells during testis development