Gene interactions and pathways from curated databases and text-mining

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EP300 — TGFB1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of E2F4-EP300 → TGFB1 (decreases)
    Evidence: TGF-beta signaling did not compete with E2F-4 for binding to TIE/E2F, but reduced p300 co-immunoprecipitating with E2F-4. Therefore, TGF-beta signaling may suppress c-myc promoter activity by dissociating p300 from E2F-4.