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TGFB1 — TIMP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nuttall et al., Endocrinology 2000
:
There was no effect of these growth factors on gelatinase or
TIMP-1 , -2, and -3, nor was there an
effect of
transforming growth factor-beta on any MMP or TIMP examined
Yabushita et al., J Obstet Gynaecol Res 2000
(Adenocarcinoma...) :
The
effects of
TGF-beta 1 on cellular invasiveness, gelatinase activity, and expression of
TIMP-1 were examined in 2 endometrial adenocarcinoma cell lines, KLE and Ishikawa
Shek et al., Am J Pathol 2002
(Chronic Disease...) :
We have examined MMP and
TIMP synthesis by transformed cultured pancreatic stellate cells and their
regulation by
TGF-beta 1
Asanuma et al., Kidney Int 2002
:
In contrast,
TGF-beta1 increased the activities of MMPs-2 and -9 ( 3.23-fold at 10 ng/mL and 25.3-fold at 10 ng/mL, respectively ) from differentiated podocytes, but did not enhance the secretion of its inhibitor,
TIMP-2
Cotrim et al., J Periodontol 2002
(Gingival Overgrowth) :
To determine the
effect of
TGF-beta1 on the expression of MMP and
TIMP by human gingival fibroblasts under CsA treatment, human gingival fibroblast cultures were treated with sense oligonucleotides (SON) or antisense oligonucleotides ( AON )
Salmela et al., Mod Pathol 2003
(Graft vs Host Disease) :
In agreement with previous data on cancer cells,
TIMP-3 ,
induced by
TGF-beta1 , may contribute to the apoptosis of keratinocytes in cutaneous graft-versus-host disease lesions, leading to typical histopathological changes
McKaig et al., Am J Pathol 2003
(Colitis, Ulcerative...) :
Recombinant ( r )
TGF-beta 1 and rTGF-beta 2, but not rTGF-beta 3,
induced expression of
TIMP-1 in normal intestinal myofibroblasts
Kordula et al., FEBS Lett 1992
(Carcinoma, Hepatocellular...) :
We show at mRNA and protein levels that
TIMP-1 is expressed in differentiated human hepatoma cells ( HepG2 ) and that its synthesis is
up-regulated by interleukin-6 (IL-6),
transforming growth factor beta 1 and phorbol 12-myristate 13-acetate
Zhou et al., Am J Physiol Cell Physiol 2005
:
TIMP-1 is
induced by
transforming growth factor-beta1 ( TGF-beta1 ), but details regarding signaling pathways remain unclear
Young et al., FEBS J 2005
:
Differential effects of histone deacetylase inhibitors on phorbol ester- and
TGF-beta1 induced murine
tissue inhibitor of metalloproteinases-1 gene expression ... Expression of the
tissue inhibitor of metalloproteinases-1 ( Timp-1 ) gene can be
induced by either phorbol myristate acetate ( PMA ) or
transforming growth factor beta1 ( TGF-beta1 ), although the signalling pathways involved are not clearly defined ... The repression of
TGF-beta1 induced
Timp-1 by TSA was maximal at 5 ng.mL(-1), while for the superinduction of PMA induced Timp-1 expression, the maximal dose is > 500 ng x mL(-1) TSA ... A further HDACi, valproic acid, did not block
TGF-beta1 induced
Timp-1 expression, demonstrating that different HDACs impact on the induction of Timp-1
Hsu et al., J Biomed Sci 2005
(Liver Cirrhosis) :
Sm ( 200 and 400 microg/ml ) significantly inhibited
TGF-beta1 stimulated alpha-SMA secretion and the mRNA expressions of alpha-SMA, CTGF, and
TIMP-1 in HSC-T6 cells
Akool et al., J Biol Chem 2005
:
We examined whether
transforming growth factor beta ( TGFbeta ), a potent profibrotic cytokine, is
involved in the regulation of NO-dependent
TIMP-1 expression
Kwak et al., Mol Cancer Res 2006
(Fibrosarcoma...) :
Because augmentation of TIMP-1 might be the major factor for the anti-invasive and antimigrative activity of TGF-beta1, we investigated possible molecular mechanisms responsible for the expression of
TIMP-1 induced by
TGF-beta1 ... Among these kinases, the inhibition of only ERK1/2 pathway by PD98059, a specific inhibitor of MAPK/ERK kinase(MEK)-1, and transfection of dominant negative MEK 1 effectively blocked the
TIMP-1 induction by
TGF-beta1 ... Mithramycin, a specific inhibitor of Sp1 transcription factor, but not curcumin, an inhibitor of activator protein-1, and transfection of Sp1 small interfering RNA significantly inhibited the
TGF-beta1 induced expression of
TIMP-1
Zeng et al., J Huazhong Univ Sci Technolog Med Sci 2006
:
In order to investigate the
effects of
TGF-beta1 on the expression of MMP-2, -9 and
TIMP-1 in human retinal pigment epithelial (RPE) cells, the third-sixth passage cultured RPE cells were treated with TGF-beta1 at different concentrations ( 0.01, 0.1, 1.0, 10 ng/mL ), the expression of MMP-2, -9 and TIMP-1 mRNA was detected by semi-quantitative RT-PCR assays
Gui et al., Dig Dis Sci 2007
:
We conclude that emodin effectively inhibits PMA- and
TGFbeta1 stimulated
TIMP-1 expression in hepatic stellate cells by suppressing the AP-1 signaling pathway and extracellular signal regulated kinase activation, respectively
Zhang et al., J Gerontol A Biol Sci Med Sci 2006
(Albuminuria...) :
It was found that the expressions and activities of gelatinases were downregulated ; the expressions of ICAM-1, collagen III, collagen IV, and
transforming growth factor (TGF)-beta1 were upregulated ; and the number of infiltrating macrophages was
increased in kidneys of 24-month-old TIMP-1 transgenic mice with high expressions of
TIMP-1 , compared with wild-type mice
Zhou et al., J Allergy Clin Immunol 2007
(Asthma...) :
These results indicate that IL-13 augments
TGF-beta1 induced
TIMP-1 expression through increased Smad phosphorylation ... This augmentation of
TGF-beta1 induced
TIMP-1 by IL-13 could contribute to the fibrosis and airway remodeling seen in the presence of T ( H ) 2 inflammation in asthma
Krag et al., Nephrol Dial Transplant 2007
(Body Weight) :
Moreover, high BG exaggerated
TGF-beta1 induced changes in the BMT, MMP-2 and
TIMP-1 expression and pERK1/2 staining
Zhang et al., Zhonghua Gan Zang Bing Za Zhi 2007
(Hepatitis B, Chronic...) :
TGFbeta1 and
TIMP-1 are involved in the course of developing hepatic fibrosis and TIMP-1 may be
regulated by
TGFbeta1
Del Carlo et al., J Urol 2008
(Penile Induration) :
These data show that, while interleukin-1beta strongly induces matrix metalloproteinase expression,
transforming growth factor-beta strongly
induces TIMP expression without any effect on matrix metalloproteinases and may represent an important downstream biochemical mechanism that leads to the progression of Peyronie 's disease
Todorova et al., Respir Med 2009
(Asthma) :
TGFbeta1 significantly
increased production of PGs and
TIMP-1 , and the activity of MMP-3, MMP-9 and MMP-2
Deng et al., Mol Cell Biochem 2010
:
Functionally,
TGF-beta1 induced an increase in MMP-9 expression, as well as decreased expression of
TIMP-1 and collagen IV, which were all restored by the FAK siRNA transfection
Overall et al., J Cell Physiol 1995
:
In contrast,
TGF-beta 1 increased
TIMP-1 mRNA levels by 3.5-fold at 24 hr to > 10-fold at 72 hr without alterations in mRNA stability indicating that transforming growth factor (TGF)-beta 1 also acts at the transcriptional level to upregulate TIMP-1 expression in bone cells
Günther et al., Arthritis Rheum 1994
:
Transforming growth factor beta 1 regulates
tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes ... To investigate the
role of interleukin-6 (IL-6) and
transforming growth factor beta 1 ( TGF beta 1 ) in the regulation of
tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) synthesis in human articular chondrocytes
Marti et al., Am J Pathol 1994
(Nephritis) :
This effect was independent of the stimulatory
effect of
TGF-beta 1 on
TIMP-1 synthesis, which was maximal in a lower concentration range ( 0.1 to 1 ng/ml )
Edwards et al., Exp Gerontol 1996
:
We conclude that the
effects of
TGF beta 1 on MMP and
TIMP gene expression involve different cellular intermediaries, and suggest that altered composition or modification of TIE binding factors in aging cells may underlie the failure of TGF beta 1-mediated transcription repression
Gatsios et al., Eur J Biochem 1996
:
We found that
transforming growth factor beta 1 as well as interleukin-1 beta
induce gene expression of both
TIMP-1 and TIMP-3
Zeng et al., Exp Cell Res 1996
:
This suggested the hypothesis that the age-specific modulation of collagenase, stromelysin, and
TIMP-1 expression is the
result of a change in
TGF-beta1 activity during replicative senescence
Huang et al., J Clin Endocrinol Metab 1998
:
We have investigated the
roles of IL-1 beta and
transforming growth factor-beta ( TGF beta ) in regulating
TIMP-1 , TIMP-3, and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR
Pawluczyk et al., Kidney Int 1998
(Cicatrix) :
TGF-beta 1 : TNF-alpha and TGF-beta 1 : IL-1 beta
induced additive increases in
TIMP-1 ( tissue inhibitor of metalloproteinases-1 ) mRNA levels
Fabunmi et al., Circ Res 1998
(Arteriosclerosis) :
Human smooth muscle cells constitutively expressed TIMP-1, -2 and -3 proteins ; platelet derived growth factor and
transforming growth factor-beta augmented levels of
TIMP-1 and TIMP-3 but not TIMP-2
Knittel et al., J Hepatol 1999
:
In general, TNF-alpha stimulated both MMP and TIMP expression of hepatic stellate cells, while
TGF-beta1 induced
TIMP expression only