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MAPK13 — RIPK2
Pathways - manually collected, often from reviews:
-
KEGG Shigellosis:
RIPK2
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
KEGG Tuberculosis:
RIPK2
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
Text-mined interactions from Literome
Lamkanfi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of pro-IL-1beta, and
RIP2 dependent activation of NF-kappaB and p38
MAPK mediated by the caspase recruitment domain
Windheim et al., Biochem J 2007
:
We also show that
RIP2 induces the activation of the protein kinase TAK1 ( transforming-growth-factor-beta activated kinase-1 ), that a dominant negative mutant of TAK1 inhibits RIP2 induced activation of JNK ( c-Jun N-terminal kinase ) and p38alpha
MAPK , and that signalling downstream of NOD2 or RIP2 is reduced by the TAK1 inhibitor ( 5Z ) -7-oxozeaenol or in TAK1-deficient cells
Duprez et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
Depending on the cell type and conditions,
RIPK1 mediates
MAPK and NF-?B activation as well as cell death
Taxman et al., J Dent Res 2012
(Chronic Periodontitis...) :
We show that pharmacological inhibition of RIPK2 represses PGE ( 2 ) secretion, and RNAi mediated silencing of
RIPK2 leads to diminished
MAPK activation and PGE ( 2 ) secretion