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BCL10 — IL15

Text-mined interactions from Literome

Masuda et al., J Biol Chem 2001 : In addition, the transcriptional activity of the bcl-x ( L ) promoter was increased by IL-15 in MC/9 cells ... In an electrophoretic mobility shift assay, IL-15 induced STAT6 binding to the STAT recognition site in the bcl-x ( L ) gene promoter ... Furthermore, the expression of a dominant negative form of STAT6 abrogated the effects of IL-15 on both bcl-x ( L ) mRNA up-regulation and prevention of apoptosis in mast cells
Kurowska et al., J Immunol 2002 (Arthritis, Rheumatoid) : Next, we investigated the effects of exogenous or endogenous IL-15 on Bcl-2 and Bcl-x ( L ) expression, FLS proliferation, and apoptosis ... Exogenous IL-15 enhanced RA FLS proliferation and increased the level of mRNA encoding Bcl-x ( L ) ... We found that blocking IL-15 biological activities using this protein substantially reduced endogenous expression of Bcl-2 and Bcl-x ( L ), and RA FLS proliferation that was reflected by increased apoptosis
Ilangumaran et al., J Immunol 2003 (Lymphoproliferative Disorders) : However, IL-15 and IL-2 induce comparable levels of Bcl-2 and Bcl-x ( L ) in SOCS1-deficient and SOCS1-sufficient CD8+ T cells, suggesting that cytokine receptor signals required for inducing proliferation and cell survival signals are not identical