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ANXA6 — TNF

Text-mined interactions from Literome

Kwon et al., J Biol Chem 1999 (Insulin Resistance) : TNFalpha inhibited p70 ( s6k ) activation by glucose stimulated beta-cells of the islets of Langerhans in a dose- and time dependent manner, with maximal inhibition observed at approximately 20-50 ng/ml, detected after 24 and 48 h of exposure ... Exogenous insulin failed to prevent TNFalpha induced inhibition of p70 ( s6k ), suggesting a defect in the insulin signaling pathway ... Furthermore, the ability of IL-1 receptor antagonist protein, IRAP, to block TNFalpha induced inhibition of p70 ( s6k ) indicated that activation of intra-islet macrophages and the release of IL-1 that induces iNOS expression in beta-cells was responsible for the inhibitory effects of TNFalpha
Jana et al., J Neurochem 2003 : Interestingly, we have found that IL-12 p70 , p402 ( the p40 homodimer ) and p40 ( the p40 monomer ) dose-dependently induced the production of TNF-alpha and the expression of TNF-alpha mRNA in BV-2 microglial cells ... In addition to BV-2 microglial cells, p70 , p402 and p40 also induced the production of TNF-alpha in mouse primary microglia and peritoneal macrophages
Pedersen et al., Scand J Immunol 2005 (Breast Neoplasms) : Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + tumour necrosis factor-alpha (TNF-alpha) induced significant IL-12 p70 secretion, which was increased after addition of a decoy IL-10 receptor
Plaisance et al., Am J Physiol Endocrinol Metab 2008 : Rapamycin inhibited TNF-alpha induced phosphorylation of the mTOR C1 target p70 ( S6K ) without altering TNF-alpha induced PS and 4E-BP1 phosphorylation
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF, TNF-alpha , and surface CD40L
Camici et al., Eur Heart J 2010 (Carotid Artery Diseases...) : Similar to rapamycin, everolimus and zotarolimus abrogated TNF-alpha induced p70S6K phosphorylation under these conditions
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : The aim of this study was to compare the effects of TNF-alpha , IL-1beta and IFN-gamma on the activation of protein kinase B (PKB), p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Kim et al., J Pharmacol Exp Ther 2011 : Furthermore, luteolin inhibited TNF-a induced phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ), mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun, and Akt/p70 ( S6K )
Heinzel et al., J Immunol 1996 (Endotoxemia) : Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold, but serum IL-12 p40 and IL-12 p70 responses increased by only twofold or less