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BDNF — TNF
Text-mined interactions from Literome
Aloe et al., Brain Res 1999
(Nervous System Diseases) :
In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system ( CNS ), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits ( Tg6074 ) the other showing no neurological or phenotypical alterations ( TgK3 ) to investigate the
effect of
TNF-alpha on brain nerve growth factor (NGF) and
brain derived neurotrophic factor (BDNF) levels and learning abilities
Bayas et al., Cytokine 2002
:
In contrast,
BDNF expression was
reduced by
TNF-alpha in human umbilical vein endothelial cells ( HUVEC )
Golan et al., Cereb Cortex 2004
:
Moreover, lack of
TNFalpha increased the expression of nerve growth factor (NGF), but not
brain derived neurotrophic factor (BDNF) , following performance of the learning task
Jornot et al., Rhinology 2007
(Nasal Polyps) :
On the other hand,
TNFalpha , IL-1beta, and IFN-gamma did not affect DPP-IV activity but significantly
increased the cellular expression and the basolateral secretion of
BDNF
Saha et al., J Neuroimmune Pharmacol 2006
:
Up-regulation of
BDNF in astrocytes by
TNF-alpha : a case for the neuroprotective role of cytokine ... Activation of NF-kappaB by TNF-alpha and inhibition of
TNF-alpha induced
BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB ... Among three MAP kinases,
TNF-alpha induced
BDNF up-regulation was sensitive only to inhibitors of ERK MAP kinase
Lee et al., J Orthop Res 2011
(Intervertebral Disc Degeneration...) :
In this study, we investigated the
effects of inflammatory cytokines, IL-1ß, and
TNF-a , on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors, nerve growth factor (NGF) and
brain derived neurotrophic factor (BDNF) , in human IVD degeneration ... IL-1ß and
TNF-a stimulated the gene expression of VEGF, NGF, and
BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Bałkowiec-Iskra et al., Neuroscience 2011
(Inflammation) :
Tumor necrosis factor-a increases
brain derived neurotrophic factor expression in trigeminal ganglion neurons in an activity dependent manner
Lin et al., Journal of neuroinflammation 2011
(Hyperalgesia...) :
The cellular mechanism of
TNF-a induced
BDNF and/or trkB receptor expression was examined in primary DRG cultures collected from pooled L1-L6 DRGs. Calcitonin gene related peptide (CGRP), BDNF and substance P release were also evaluated by enzyme immunoassay