Lohmann et al., Brain Res 2004
:
PAO induced occludin proteolysis could be prevented by different MMP inhibitors
Reijerkerk et al., FASEB J 2006
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Diapedesis of monocytes is associated with MMP mediated occludin disappearance in brain endothelial cells
Huang et al., FASEB J 2009
:
Indeed, the HIV induced decrease in the expression of JAM-A and occludin was restored by inhibition of MMP activity
Lischper et al., Brain Res 2010
:
MMP inhibition by the metalloproteinase inhibitor GM6001 prevented occludin degradation and reduced the intercellular gap formation
Liu et al., J Neurosci 2012
(Brain Ischemia...) :
These data indicate that cerebral ischemia initiates two rapid parallel processes, MMP-2 mediated occludin degradation and Cav-1 mediated claudin-5 redistribution, to cause BBB disruption at early stroke stages relevant to acute thrombolysis