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EGF — SMAD7

Text-mined interactions from Literome

Diamond et al., J Cell Sci 2008 (Carcinoma, Squamous Cell...) : Mechanistically, EGF enhanced Smad phosphorylation in the linker region, and attenuated TGFbeta1 mediated phosphorylation of Smad at the C-terminus, localization of Smad to the nucleus as well as Smad-driven promoter activity exclusively in oral keratinocytes but not in OSCC cells ... The effect of EGF on TGFbeta1 mediated Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked
Kim et al., Cancer Lett 2012 (Breast Neoplasms) : The expression of smad7 and MMP-9 was increased by EGF or TGF-ß1, respectively, and further increased by EGF and TGF-ß1 co-treatment
de Caestecker et al., Genes Dev 1998 : We demonstrate here that HGF and EGF , which signal through RTKs, can also mediate SMAD dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase ( s ) downstream of MEK1