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HMOX1 — TGFB1

Text-mined interactions from Literome

Hill-Kapturczak et al., J Biol Chem 2000 : Smad7 dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells ... We hypothesize that the release of TGF-beta1 via autocrine and/or paracrine pathways may induce HO-1 and serve as a protective response in renal injury ... To understand the molecular mechanism of HO-1 induction by TGF-beta1 , we exposed confluent human renal proximal tubule cells to TGF-beta1 and observed a significant induction of HO-1 mRNA at 4 h with a maximal induction at 8 h ... Overexpression of Smad7, but not Smad6, inhibited TGF-beta1 mediated induction of endogenous HO-1 gene expression
Ning et al., Am J Physiol Lung Cell Mol Physiol 2002 : TGF-beta1 stimulates HO-1 via the p38 mitogen activated protein kinase in A549 pulmonary epithelial cells ... Here we report that TGF-beta1 is a potent inducer of HO-1 and examined the signaling pathway by which TGF-beta1 regulates HO-1 expression in human lung epithelial cells ( A549 ) ... Both SB-203580 and expression of a dominant negative mutant of p38 MAPK inhibited TGF-beta1 induced ho-1 gene activation, as assayed by luciferase activity of an ho-1 enhancer/luciferase fusion construct ( pMHO1luc-33+SX2 ) ... These studies demonstrate the critical intermediacy of the p38 MAPK pathway in the regulation of HO-1 expression by TGF-beta1
Abdel-Aziz et al., Int J Biochem Cell Biol 2003 : Also, the effect of HO-1 on the expression of transforming growth factor beta ( TGF-beta ), was studied in the presence and absence of HO-1 inducers
Hartung et al., Molecular vision 2007 : Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells
Lin et al., Eur J Pharmacol 2007 : Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells ... A previous report showed that transforming growth factor-beta1 ( TGF-beta1 ) can induce heme oxygenase-1 (HO-1) expression, attenuate cellular injury, and maintain tissue homeostasis ... In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signaling pathway in TGF-beta1 induced HO-1 expression in human lung epithelial cells ( A549 ) ... Treatment of A549 cells with LY 294002 ( 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one, a PI3K inhibitor ), an Akt inhibitor, and the dominant negative mutant of Akt ( Akt DN ) inhibited TGF-beta1 induced HO-1 expression and HO-1-luciferase activity ... In addition, treatment of A549 cells with Bay 117082 ( ( E ) -3- [ 4-methylphenylsulfonyl ] -2-propenenitrile, an IkappaB phosphorylation inhibitor ), pyrrolidine dithiocarbamate ( PDTC, an NF-kappaB inhibitor ), and the dominant negative mutant of IkappaBalpha ( IkappaBalphaM ) inhibited TGF-beta1 induced HO-1 expression and HO-1-luciferase activity ... The TGF-beta1 mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN. Taken together, these results suggest that the PI3K/Akt dependent IKKalpha/beta/NF-kappaB signaling pathway plays an important role in TGF-beta1 induced HO-1 expression in A549 cells
Traylor et al., American journal of physiology. Renal physiology 2007 : Specificity protein 1 and Smad dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells ... Little is known regarding the molecular regulation of human HO-1 induction by TGF-beta1 except that it is dependent on de novo RNA synthesis and requires a group of structurally related proteins called Smads ... It is not known whether other DNA binding proteins are required to initiate transcription of HO-1 and, furthermore, the promoter region ( s ) involved in TGF-beta1 mediated induction of HO-1 has not been identified ... The purpose of this study was to further delineate the molecular regulation of HO-1 by TGF-beta1 in human renal proximal tubular cells ... This approximately 280-bp TGF-beta1-responsive region contains a putative Smad binding element and specificity protein 1 binding sites, both of which are required for human HO-1 induction by TGF-beta1
Xia et al., Am J Pathol 2007 (Asthma...) : Thus, we postulated that induction of HO-1 could augment IL-10 and transforming growth factor ( TGF ) -beta production and foxp3+CD4+CD25+ Treg cell function, thereby leading to attenuation of airway inflammation
Churchman et al., J Cell Mol Med 2009 : This study investigates whether activation of the Nrf2 ( nuclear factor erythroid 2 [NF-E2 ] -related factor 2 ) transcription pathway is involved in TGF-beta(1) mediated induction of the antioxidant enzyme heme oxygenase-1 (HO-1) in smooth muscle cells ( SMC ) ... We report the first evidence that TGF-beta(1) induces Nrf2 mediated HO-1 expression and antioxidant response element activity, which was paralleled by enhanced superoxide production and expression of the NAD ( P ) H oxidase subunit p22(phox) ... TGF-beta(1) failed to induce HO-1 expression in MAoSMC derived from Nrf2-deficient mice, and HO-1 induction by TGF-beta(1) in HAoSMC was attenuated by inhibition of extracellular signal regulated kinase or c-jun-N-terminal kinase but not p38 mitogen activated protein kinase ... Inhibition of NAD ( P ) H oxidase or scavenging of superoxide diminished HO-1 induction in response to TGF-beta(1) ... The oxidative stress agents glucose oxidase (GOx) and diethylmaleate enhanced TGF-beta(1) generation and HO-1 expression in HAoSMC, while antagonism of TGF-beta(1) signalling by adenoviral Smad7 overexpression attenuated their induction of HO-1
Kutty et al., J Cell Physiol 1994 : The induction of HO-1 by TGF-beta 1 was also observed in bovine choroid fibroblasts, but not in HELA, HEL or bovine corneal fibroblasts