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LTBP4 — TGFB1

Pathways - manually collected, often from reviews:

• Reactome Reaction: TGFB1 → LTBP4 (reaction) Isogai et al., J Biol Chem 2003*
• Reactome Reaction: TGFB1 → LTBP4 (indirect_complex) Isogai et al., J Biol Chem 2003*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TGFB1 — LTBP4 (in vivo) Saharinen et al., J Biol Chem 1998*
• IRef Ophid Interaction: TGFB1 — LTBP4 (aggregation, confirmational text mining) Saharinen et al., J Biol Chem 1998*
• IRef Ophid Interaction: TGFB1 — LTBP4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Zhou et al., Am J Pathol 2009 (Pulmonary Fibrosis) : Bleomycin induced TGF-beta1 activation required LTBP-4 , since lung fibroblasts deficient in LTBP-4 did not activate TGF-beta1 ... Expression of LTBP-4 restored TGF-beta1 activation in response to bleomycin, but expression either of LTBP-4 lacking the TGF-beta binding site or only the TGF-beta binding domain did not ... Together, these data identify a critical role for LTBP-4 in the regulation of latent TGF-beta1 activation in bleomycin induced lung fibrosis
Ando et al., Kidney Int 1995 : LTBP plays a central role in the assembly, secretion and activation of TGF-beta 1
Taipale et al., J Cell Biol 1994 (Fibrosarcoma) : The role of latent transforming growth factor-beta ( TGF-beta ) binding protein ( LTBP ) in the association of TGF-beta 1 to the extracellular matrix of cultured fibroblasts and HT-1080 fibrosarcoma cells was studied by immunochemical methods
Waltenberger et al., J Immunol 1993 : LTBP was induced simultaneously with TGF-beta 1 and occurred within interstitial spaces of the myocardium