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Secchiero et al., Blood 2004
(MAP Kinase Signaling System) :
Among the intracellular pathways investigated, TRAIL significantly stimulated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the p38/mitogen activated protein kinase ( MAPK ) or the c-Jun NH2-terminal kinase (JNK) pathway
Sun et al., Oncol Rep 2011
:
Taken together, we show herein that the upstream molecule of the TRAIL induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner