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AXIN2 — GSK3B

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: AXIN1/AXIN2 → GSK3B (protein-protein, binding/association)
• KEGG Endometrial cancer: Complex of APC-APC2-AXIN1-AXIN2-GSK3B → CTNNB1 (protein-protein, missing interaction)
• NCI Pathway Database Degradation of beta catenin: APC/beta catenin complex (APC-CTNNB1) → Axin2/APC/GSK3/beta catenin complex (AXIN2-APC-GSK3B_GSK3A-CTNNB1) (modification, collaborate)
  Liu et al., Curr Biol 2005, Behrens et al., Science 1998, Yamamoto et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: APC/beta catenin complex (APC-CTNNB1) → Axin2/GSK3 complex (AXIN2-GSK3B_GSK3A) (modification, collaborate)
  Liu et al., Curr Biol 2005, Behrens et al., Science 1998, Yamamoto et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: Axin2/APC/GSK3/beta catenin complex (AXIN2-APC-GSK3B_GSK3A-CTNNB1) → Axin2/GSK3 complex (AXIN2-GSK3B_GSK3A) (modification, collaborate)
  Liu et al., Curr Biol 2005, Behrens et al., Science 1998, Yamamoto et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• WikiPathways Neural Crest Differentiation: AXIN2/AXIN1 → GSK3B (mim-necessary-stimulation)
• WikiPathways Wnt/beta-catenin Signaling Pathway in Leukemia: AKT1 → Complex of AXIN2-APC-CSNK1A1-GSK3B (mim-stimulation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AXIN2 — GSK3B (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: AXIN2 — GSK3B (physical association, affinity chromatography technology) von Kries et al., Nat Struct Biol 2000*
• IRef Biogrid Interaction: AXIN2 — GSK3B (physical association, affinity chromatography technology) Schwarz-Romond et al., Genes Dev 2002*
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Ophid Interaction: AXIN2 — GSK3B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: AXIN2 — GSK3B (aggregation, confirmational text mining) von Kries et al., Nat Struct Biol 2000*

Text-mined interactions from Literome

Hedgepeth et al., Mol Cell Biol 1999 : Similarly, mutants of axin lacking key regulatory domains such as the RGS domain, which is required for interaction with the adenomatous polyposis coli protein, bind and inhibit GSK-3beta in vivo, suggesting that these domains are critical for proper regulation of GSK-3beta activity ... We have identified a novel self-interaction domain in axin and have shown that formation of an axin regulatory complex in vivo is critical for axis formation and GSK-3beta activity ... Based on these data, we propose that the axin complex may directly regulate GSK-3beta enzymatic activity in vivo
Chen et al., J Biol Chem 2009 : The Ser and Thr residues in the motif appear to be also phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) and the CKI family kinases, as GSK3beta and CKIepsilon could enhance the interaction of Zbed3 with Axin