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STAT3 — TWIST1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lo et al., Cancer Res 2007
(Breast Neoplasms...) :
Furthermore, constitutively active
STAT3 significantly
activates the
TWIST promoter, whereas the JAK/STAT3 inhibitor and dominant negative STAT3 suppressed TWIST promoter ... Together, we report here that EGF/EGFR signaling pathways induce cancer cell EMT via
STAT3 mediated
TWIST gene expression
Cheng et al., J Biol Chem 2008
(Breast Neoplasms) :
Twist is transcriptionally
induced by activation of
STAT3 and mediates STAT3 oncogenic function ... Our results indicate that activated
STAT3 transcriptionally
induces Twist , which plays an important role in promoting migration, invasion, and anchorage independent growth
Cho et al., Cancer Lett 2013
(Disease Progression...) :
STAT3 mediates TGF-ß1 induced
TWIST1 expression and prostate cancer invasion ... Further ectopic expression of a dominant negative mutant of
STAT3 reduced TGF-ß1 induced
TWIST1 expression ... In addition,
STAT3 and HIF-1a
up-regulated TWIST1 expression by direct binding to a TWIST1 promoter ... Strikingly,
STAT3 also
enhanced TGF-ß1 induced
TWIST1 expression through HIF-1a stabilization