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CEBPE — MYC
Text-mined interactions from Literome
Gery et al., Blood 2004
:
Finally, overexpression of
C/EBPepsilon in human myeloid cells
leads to down-regulation of
c-Myc
Cai et al., Chin J Cancer 2006
:
This study was to detect the cell-specific expression of C/EBPepsilon, and to investigate the
effect of
C/EBPepsilon overexpression on
c-Myc expression, cell cycle distribution, and cell differentiation of human myelomonocytic leukemia cell line U-937
Matsushita et al., Oncogene 2008
(Leukemia, Myeloid, Acute) :
These findings suggest that the ectopic expression of
C/EBPepsilon , as well as C/EBPalpha, can
induce the monocytic differentiation of myelomonocytic leukemic cells with MLL-fusion gene through the downregulation of
Myc , thus providing insight into the development of novel therapeutic approaches