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FGF2 — HSPG2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGF2 → Complex of FGF2-HSPG2 (increases)
  Evidence: For instance, syndecan inhibits the mitogenic activity of FGF2 whereas perlecan promotes FGF2-induced cell proliferation and angiogenesis (reviewed in [128]).
• OpenBEL Selventa BEL large corpus: FGF2 → HSPG2 (increases)
  Evidence: For instance, syndecan inhibits the mitogenic activity of FGF2 whereas perlecan promotes FGF2-induced cell proliferation and angiogenesis (reviewed in [128]).
• Reactome Reaction: FGF2 → HSPG2 (direct_complex) Knox et al., J Biol Chem 2002*
• Reactome Reaction: FGF2 → HSPG2 (reaction) Knox et al., J Biol Chem 2002*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: HSPG2 — FGF2 (in vivo) Knox et al., J Biol Chem 2002*
• IRef Matrixdb Interaction: HSPG2 — FGF2 (direct interaction, far western blotting) Zoeller et al., Matrix Biol 2009*
• IRef Ophid Interaction: HSPG2 — FGF2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tappia et al., Biochem Cell Biol 1999 : FGF-2 , administered by retrograde perfusion to the isolated heart, induced an increase in inositol-1,4,5-trisphosphate levels in the cytosol, as well as an increase in total PI-PLC activity associated with sarcolemmal and cytosolic fractions
Zhang et al., Blood 2004 : The previously established key role of perlecan in mediating bFGF stimulation of endothelial cell proliferation and angiogenesis suggests that a primary mechanism by which antiangiogenic antithrombins exert their effects is through the down-regulation of perlecan expression
Kaji et al., Yakugaku Zasshi 2004 (Arteriosclerosis) : On the other hand, lead does not exhibit cytotoxicity but inhibits the repair of endothelial monolayers after wounding by a lower response to endogenous basic fibroblast growth factor mediated by suppression of the synthesis of perlecan , a large heparan sulfate proteoglycan
Zhou et al., Cancer Res 2004 (Neoplasms, Experimental...) : Both stimulatory and inhibitory effects of perlecan on FGF-2 signaling have been reported
Smith et al., Matrix Biol 2007 : When digested with chondroitinase ABC to remove its CS chains, perlecan augmented binding of FGF-2 to the FGFR-1 and FGFR-3 receptors and also increased FGF-2 stimulation of [ ( 3 ) H ] -thymidine incorporation in BaF3 cells expressing these FGF receptors
Oh et al., J Neurosci Res 2008 : bFGF stimulation resulted in activation of phospholipase C-gamma (PLC-gamma) and an increased level of intracellular Ca2+
Mashayekhi et al., J Mol Neurosci 2011 : Perlecan can promote fibroblast growth factor-2 (FGF-2) activity ... In this study the effects of FGF-2 on neurogenesis and perlecan expression in the cerebral cortex have been studied ... In conclusion, the results from this study suggest that FGF-2 increases neural cell production and perlecan expression in the developing cerebral cortex
Aviezer et al., Cell 1994 (Neovascularization, Pathologic) : Perlecan , basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
Muslin et al., Mol Cell Biol 1994 : These results demonstrate that PLC gamma activation by the FGF receptor is not required for FGF stimulated mesoderm induction
Aviezer et al., Mol Cell Biol 1997 : Furthermore, receptor binding and affinity labeling of antisense perlecan transfected cells with 125I-bFGF is markedly inhibited, indicating that eliminating perlecan expression results in reduced high-affinity bFGF binding
Curto et al., Biochem Biophys Res Commun 1998 : In response to fibroblast growth factor ( FGF ) , FGF receptor-1 (FGFR-1) ( flg ) becomes tyrosine phosphorylated and associates with phospholipase C gamma (PLC gamma) and a 90 kDa protein