Zhu et al., Biochem Pharmacol 2008
(Neoplasms) :
Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells ... We report here that microRNAs miR-27a and miR-451 are involved in activating the expression of P-glycoprotein , the MDR1 gene product that confers cancer cell resistance to a broad range of chemotherapeutics
Chen et al., Med Oncol 2012
(Breast Neoplasms) :
Up-regulation of miR-200c with transfection of miR-200c mimics in breast cancer cells could enhance the chemosensitivity to epirubicin and reduce expression of multidrug resistance 1 mRNA and P-glycoprotein Bao et al., Am J Pathol 2012
(Breast Neoplasms...) :
Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298 Yang et al., Oncol Rep 2013
:
Thus, expression of miR-195 or knockdown of Raf-1 can similarly reduce tumor cell survival but increase apoptosis through downregulation of Raf-1 and Bcl-2 and P-glycoprotein expression