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F2R — PTGS2

Text-mined interactions from Literome

Sekiguchi et al., Biochem Pharmacol 2007 : The PAR1 activating peptide (PAR1-AP) and thrombin increased PGE ( 2 ) release from RGM1 cells for 18h, an effect being suppressed by inhibitors of COX-1, COX-2 , MEK, p38 MAP kinase (p38 MAPK), protein kinase C ( PKC ), Src and EGF receptor-tyrosine kinase (EGFR-TK), but not JNK and matrix metalloproteinase ( MMP ) /a disintegrin and metalloproteinases ( ADAMs ) ... PAR1-AP up-regulated COX-2 in a manner dependent on MEK and EGFR-TK, but not p38 MAPK
Osuga et al., Front Biosci (Elite Ed) 2012 (Endometriosis) : PAR1 activation in endometriotic stromal cells induces production of IL-8, monocyte chemotactic protein-1, and cyclooxygenase-2 , and proliferation of the cells
Osuga et al., Front Biosci (Schol Ed) 2012 (Endometriosis) : PAR1 activation in endometriotic stromal cells induces production of IL-8, monocyte chemotactic protein-1, and cyclooxygenase-2 , and proliferation of the cells