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PTEN — TXN

Text-mined interactions from Literome

Lee et al., J Biol Chem 2002 : Thioredoxin co-immunoprecipitated with PTEN from cell lysates ; and incubation of cells with 2,4-dinitro-1-chlorobenzene ( an inhibitor of thioredoxin reductase ) delayed the reduction of oxidized PTEN , whereas incubation with buthioninesulfoximine ( an inhibitor of glutathione biosynthesis ) did not
Meuillet et al., Arch Biochem Biophys 2004 : Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN 's lipid phosphatase activity and membrane binding : a mechanism for the functional loss of PTEN 's tumor suppressor activity ... The results of the study suggest that the increased levels of Trx-1 in human tumors could lead to functional inhibition of PTEN tumor suppressor activity providing an additional mechanism for tumorigenesis with loss of PTEN activity
Hui et al., Proc Natl Acad Sci U S A 2008 (Insulin Resistance...) : In the absence of Txnip, oxidative inactivation of PTEN and subsequent activation of Akt attenuated mitochondrial respiration, resulting in the accumulation of NADH, a competitive inhibitor of thioredoxin NADPH-reductive activation of PTEN