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IL2 — RHOA
Pathways - manually collected, often from reviews:
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NCI Pathway Database SHP2 signaling:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Helms et al., J Leukoc Biol 2007
:
We have shown further that
RhoA inhibits NFAT dependent transcription and
IL-2 production in human T cells
Xu et al., Blood 2009
:
Finally, we demonstrated that pomalidomide was able to regulate the activity of Rho GTPases and the formation of F-actin in primary human T cells as it did in monocytes and showed that the activation of
RhoA was
essential for pomalidomide induced
interleukin-2 expression in T cells
Gómez et al., Eur J Immunol 1997
:
IL-2 , but not IL-4,
induces Bcl-2 expression through
RhoA activation which is inhibited by the specific Rho family inhibitor, Clostridium difficile Toxin B, as well as by a dominant negative RhoA mutant