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RELA — TNFRSF10B

Text-mined interactions from Literome

Hu et al., J Biol Chem 1999 (Breast Neoplasms) : TRAIL-R1 and TRAIL-R2 can induce apoptosis of cancer cells and activate the transcription factor NF-kappaB
Singh et al., Oncogene 2005 (Breast Neoplasms) : HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Shetty et al., Mol Cell Biol 2005 (Breast Neoplasms) : Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1 ... Death receptor 5 ( DR5, TRAIL-R2 ) is a proapoptotic protein considered to be a potential target for cancer therapy, and its expression is mediated by NF-kappaB
Shankar et al., Molecular cancer 2008 (Neoplasm Metastasis...) : In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5 , Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL