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CDK2 — FOXM1

Pathways - manually collected, often from reviews:

• NCI Pathway Database FOXM1 transcription factor network: RB1/FOXM1C complex (FOXM1-RB1) → Cyclin A-E1/CDK1-2 complex (CCNA2_CCNE1-CDK2) (modification, collaborate)
  Lüscher-Firzlaff et al., FEBS Lett 2006, Wierstra et al., Biochem Biophys Res Commun 2006, Wierstra et al., Biol Chem 2006
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• Reactome Reaction: FOXM1 → CDK2 (reaction) Major et al., Mol Cell Biol 2004, Laoukili et al., Mol Cell Biol 2008*, Fu et al., Nat Cell Biol 2008*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FOXM1 — CDK2 (direct interaction, enzymatic study) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Biogrid Interaction: FOXM1 — CDK2 (physical association, affinity chromatography technology) Major et al., Mol Cell Biol 2004
• IRef Hprd Interaction: FOXM1 — CDK2 (in vitro) Major et al., Mol Cell Biol 2004
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Innatedb Interaction: FOXM1 — CDK2 (unknown, -) Major et al., Mol Cell Biol 2004

Text-mined interactions from Literome

Major et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : We demonstrated that FoxM1B transcriptional activity requires binding of either S-phase or M-phase Cdk-cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue, which is essential for recruitment of p300/CBP coactivator proteins
Lüscher-Firzlaff et al., FEBS Lett 2006 : Regulation of the transcription factor FOXM1c by Cyclin E/CDK2
Wierstra et al., Biochem Biophys Res Commun 2006 : FOXM1c is activated by cyclin E/Cdk2 , cyclin A/Cdk2, and cyclin A/Cdk1, but repressed by GSK-3alpha ... Here, we demonstrate that cyclin E/Cdk2 , cyclin A/Cdk2, and cyclin A/Cdk1 activate FOXM1c ... Cyclin E/Cdk2 activates FOXM1c by releasing its transactivation domain from the repression by these two inhibitory domains
Wierstra et al., Biochem Biophys Res Commun 2008 : In contrast, we now demonstrate that this LXL-motif is not required for the activation of FOXM1c by cyclin D1/Cdk4, cyclin E/Cdk and cyclin A/Cdk2 or for the repression of FOXM1c by p27
Alvarez-Fernández et al., EMBO Rep 2010 : Recovery from a DNA-damage induced G2 arrest requires Cdk dependent activation of FoxM1 ... We have shown recently that Cdk activity is required for activation of the Forkhead transcription factor FoxM1 , an important regulator of gene expression in the G2 phase of the cell cycle