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CD40 — IL10

Text-mined interactions from Literome

Harigai et al., J Rheumatol 1999 (Arthritis, Rheumatoid) : IL-10 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus IFN-gamma induced TNF-alpha production by ST cells
Chabot et al., J Immunol 1999 : By also measuring TNF-alpha levels, specificity of cytokine regulation was observed ; while anti-CD40 and CTLA-4-Fc reduced IL-10 and TNF-alpha levels, anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation
Bartholomé et al., J Interferon Cytokine Res 1999 : IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of CD40 dependent interleukin-12 secretion
Kooy et al., J Pathol 1999 (Carcinoma, Basal Cell...) : Interferon-gamma induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 ( B7.1 ), and inconsistent HLA-ABC expression in basal cell carcinoma : a possible role for interleukin-10 ? ... It may be concluded that it is highly likely that the presence of IL-10 in BCC is directly or indirectly responsible for the complete lack of expression of HLA-DR, ICAM-1, CD40 and CD80 and the inconsistent expression of HLA-ABC on BCC cells in situ and may be a way of escaping immune survillance
Van Gool et al., Eur J Immunol 1999 : Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals
Rojas et al., Infect Immun 1999 : IL-10 down-regulated major histocompatibility complex ( MHC ) class I, MHC class II, CD40 , B7-1, and B7-2 expression on M. tuberculosis infected monocytes to a greater extent than TGF-beta
Muraille et al., Blood 1999 : Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive interleukin-12 in response to CD40 stimulation
Yamauchi et al., J Immunol 2000 (Leprosy, Lepromatous...) : Furthermore, IL-10 , a cytokine predominant in lepromatous lesions, blocked the IFN-gamma up-regulation of CD40 on monocytes
Dahlenborg et al., Immunology 2000 : Cells were first cultured in the presence of CD32L cell transfectants and CD40 antibody ( the ` CD40 system ' ) supplemented with combinations of cytokines capable of supporting similar levels of CD40 dependent GC B-cell growth [interleukin (IL)-10 + IL-1beta + IL-2 and IL-10 + IL-7 + IL-4 ]
Foey et al., Cytokine 2000 : Route of monocyte differentiation determines their cytokine production profile : CD40 ligation induces interleukin 10 expression ... The addition of exogenous IL-1 augments CD40 induced IL-10 production by IFN-gamma primed monocytes ... These data indicate that CD40 ligation regulates cell contact mediated macrophage IL-10 and that the route of differentiation determines the cytokine profile
Pietrella et al., J Infect Dis 2001 : This reduction paralleled IL-10 induction and inhibited translocation of CD40 to the surface of monocytes
Tarte et al., Leukemia 2000 (Multiple Myeloma) : In addition, mature DC obtained with TNF-alpha produced IL-12 and some IL-10 in response to CD40 stimulation
Chabot et al., J Neurosci Methods 2001 (Central Nervous System Diseases...) : Morphological features and mechanisms of cytokine production resemble those observed in microglia -- T cell co-cultures since CTLA-4 and CD40 -- CD40L blockades reduce TNF-alpha and IL-10 levels, while anti-CD23 inhibits IL-10 only in U937 -- T cell interactions
Foey et al., Cytokine 2001 : CD40 ligation induces macrophage IL-10 and TNF-alpha production : differential use of the PI3K and p42/44 MAPK-pathways ... IL-10 and tumour necrosis factor alpha (TNF-alpha) are produced by macrophage colony stimulating factor ( M-CSF ) -primed monocytes/macrophages in response to CD40 ligation ... These observations suggest that CD40 ligation induces macrophage IL-10 and TNF-alpha production, the mechanism of which is p70S6K dependent yet bifurcates at the level of PI3K and p42/44 MAPK
Reider et al., J Allergy Clin Immunol 2002 (Hypersensitivity) : Production of IL-4, IL-5, IL-10 , IL-12, and IL-13 in response to CD40 ligation was measured with ELISA
Uchimura et al., Clin Exp Immunol 2002 (Graves Disease) : The effects of CD40- and interleukin ( IL-4 ) -activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves ' disease : the role of CD8+ cells
Agematsu et al., Clin Immunol 2002 (Common Variable Immunodeficiency) : B cells from CVID patients produced IgM and IgG, but not IgA upon the engagement of Ig receptor and CD40 in the presence of IL-2 and IL-10
Kim et al., J Neuroimmunol 2002 : Inhibition of microglial CD40 expression by pituitary adenylate cyclase activating polypeptide is mediated by interleukin-10
Companjen et al., Int Immunol 2002 : IL-6, IL-8, tumor necrosis factor (TNF)-alpha, IL-12 and IL-1 beta were induced upon CD40 ligation and IFN-gamma stimulation, while IL-10 could be induced by CD40 ligation alone and was reduced again by the addition of IFN-gamma ... These data show that CD40 ligation induced secretion of IL-6 and IL-8, but not TNF-alpha and IL-10 , is partially mediated via IL-1 and that IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin
Janssen et al., Am J Respir Cell Mol Biol 2002 (Asthma...) : This IL-10 production by the OVA-Mphi was dependent on MHC-TCR and CD86-CD28, but not CD80-CD28 or CD40-CD154 interactions
Krajina et al., Eur J Immunol 2003 (Colitis...) : cLP DC from non transplanted ( healthy ) and transplanted ( diseased ) mice produce similar amounts of IL-12 p70 and IL-10 in response to CD40 signaling, but the inducible IL-12 p40 release is 5-15-fold higher in mice with colitis than in non transplanted mice
Qi et al., Infect Immun 2003 : Further, these stimuli differentially conditioned CD40 dependent IL-10 and IL-12 production by DCs
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Wagner et al., J Immunol 2004 : Similar to CpG ODN, CD40 ligand (CD40L) alone induced IL-6, TNF-alpha, and IL-10
Jeurissen et al., Eur J Immunol 2004 (Hypergammaglobulinemia) : Furthermore, we showed that caps-PS induce production of IL-4, IL-6, IL-10 , and IFN-gamma, and that this enhanced production was inhibited by blocking the CD40-CD40L interaction
Duddy et al., J Immunol 2004 (Inflammation) : In contrast, CD40 stimulation alone, a mimic of a B cell receiving bystander T cell help in the absence of specific Ag recognition, induces negligible proinflammatory cytokines, but significant production of IL-10 that serves to suppress inappropriate immune responses
Chambers et al., Immunology 2004 (Milk Hypersensitivity) : Experiments were also carried out to determine the levels of interferon-gamma (IFN-gamma) and interleukin (IL)-4 produced by splenocytes from naïve recipients following the adoptive transfer, and CD40 ligand (CD40L) mediated IL-10 production by DCs from allergic and control mice
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : Here we show that weak CD40 signals induce extracellular stress related kinase-1/2 ( ERK-1/2 ) -dependent IL-10 expression, whereas stronger signals induce p38 mitogen activated protein kinase ( p38MAPK ) -dependent IL-12 production
Cao et al., Oral Oncol 2005 (Head and Neck Neoplasms...) : CD40 ligation specifically increased the secretion of IL-8, VEGF and PGE ( 2 ) but not IL-6, IL-10 , FasL, GM-CSF, or TGFalpha
Néron et al., Immunology 2005 : Proliferation and differentiation of B lymphocytes were monitored in response to graded levels of CD40 stimulation in the presence of interleukin (IL)-2, IL-4 and IL-10
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005 (Adenocarcinoma...) : Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients, CD40 ligation induced phenotypic maturation and interleukin 12 secretion, in turn generating more efficient T-cell responses
Qin et al., J Immunol 2006 : IL-10 inhibits lipopolysaccharide induced CD40 gene expression through induction of suppressor of cytokine signaling-3 ... In this study, we discovered that IL-10 , a cytokine with anti-inflammatory properties, inhibits LPS induced CD40 gene expression ... These results indicate that SOCS-3 plays an important role in the negative regulation of LPS induced CD40 gene expression by IL-10
Danese et al., Gut 2007 (Colitis...) : Engagement of CD40 on HIFs promoted the release of vascular endothelial growth factor ( VEGF ), interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Wan et al., Arthritis Rheum 2008 (Disease Models, Animal...) : Anti-CD40 treatment induced a higher production of interleukin-6 (IL-6), soluble IL-6 receptor ( sIL-6R ), IL-10 , and tumor necrosis factor alpha in B6.TC DCs
Tuettenberg et al., Exp Dermatol 2010 : CD40 signalling induces IL-10 producing, tolerogenic dendritic cells
Dragicević et al., Vojnosanit Pregl 2011 : Stimulation of CD40 on Poly ( I:C ) -treated MoDCs significantly enhanced the production of IL-12, IL-23 and IL-10
Sarma et al., PloS one 2012 : The bi-modular architecture of the signaling pathways endows the system with an inherent plasticity which is further expressed in the skewing of the CD40 induced productions of IL-10 and IL-12, the respective anti-inflammatory and pro-inflammatory cytokines
de Andrés et al., J Immunol 2012 : Moreover, in vitro stimulation of splenic 19?45R ( lo ) cells with LPS, CpG, BAFF/IL4, and CD40/IL4 induced cell proliferation, IgG1/IgA secretion and the release of IL-10 , suggesting a potential immunoregulatory role for this subset of innate-like B cells
Malisan et al., Blood 1996 (Leukemia, Lymphocytic, Chronic, B-Cell) : Stimulation of these B-CLL cells through surface CD40 in the presence of interleukin-10 induced them to secrete IgG and IgA, proving that they can also differentiate into Ig-secreting cells
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Uejima et al., Int Arch Allergy Immunol 1996 : Effect of interleukin-10 on anti-CD40- and interleukin-4 induced immunoglobulin E production by human lymphocytes
Cella et al., J Exp Med 1996 : Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells ... In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Burdin et al., Methods 1997 : While addition of exogenous IL-4 diminishes CD40 induced secretion of IL-10 , addition of Staphyloccocus aureus Cowan I ( SAC ) particles increases it
Ravanel et al., J Exp Med 1997 (Measles) : Finally, the in vitro Ig synthesis of CD40- or Ig-activated human B lymphocytes in the presence of interleukin (IL)-2 and IL-10 was reduced by 50 % in the presence of recombinant NP
Yoshimoto et al., Eur J Immunol 1997 : Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB
Iwasaki et al., Clin Exp Immunol 1998 : CD40 also augmented tumour necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) expression but resulted in decreased IL-10 expression
Zan et al., J Immunol 1998 : In these cells, CD40 engagement by CD40 ligand induces production of endogenous TGF-beta and IL-10 , expression of germline Ialpha1-Calpha1 and Ialpha2-Calpha2 transcripts, mature VHDJH-Calpha1 and VHDJH-Calpha2 transcripts, and IgA secretion
Séguin et al., J Infect Dis 1999 : Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii