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CX3CR1 — IL2

Text-mined interactions from Literome

Barlic et al., Blood 2003 : IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1
Barlic et al., J Biol Chem 2004 : Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2 dependent mechanisms ... We have recently reported that interleukin (IL)-15 and IL-2 , which signal through IL-2Rbetagamma, oppositely regulate expression of the proinflammatory chemokine receptor CX3CR1 ... The effects of IL-15 and IL-2 on both CX3CR1 reporter activity and endogenous CX3CR1 transcription in PBMCs were abolished by the NFAT inhibitors cyclosporin A and VIVIT ... This appears to be relevant in vivo because mouse CX3CR1 mRNA was expressed in both PBMCs and splenocytes from NFAT1-/- mice injected with recombinant IL-15 but was undetectable in cells from IL-15 injected NFAT1+/+ BALB/c mice ; as predicted, IL-2 up-regulated cx3cr1 in both mouse strains to a similar extent